Mus musculus Gene: Nat2
Summary
InnateDB Gene IDBG-158899.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nat2
Gene Name N-acetyltransferase 2 (arylamine N-acetyltransferase)
Synonyms AV377607;
Species Mus musculus
Ensembl Gene ENSMUSG00000051147
Encoded Proteins
N-acetyltransferase 2 (arylamine N-acetyltransferase)
N-acetyltransferase 2 (arylamine N-acetyltransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171428:
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:67494867-67502580
Strand Forward strand
Band B3.2
Transcripts
ENSMUST00000093470 ENSMUSP00000091181
ENSMUST00000163856 ENSMUSP00000130065
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004060 arylamine N-acetyltransferase activity
GO:0016407 acetyltransferase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Phase II conjugation pathway
Metabolism pathway
Acetylation pathway
Biological oxidations pathway
KEGG
Caffeine metabolism pathway
Drug metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Phase II conjugation pathway
Acetylation pathway
Metabolism pathway
Biological oxidations pathway
Acetylation pathway
Biological oxidations pathway
Metabolism pathway
Phase II conjugation pathway
KEGG
Caffeine metabolism pathway
Drug metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.4695
RefSeq NM_001168577 NM_010874 XM_006509592
OMIM
CCDS CCDS22338
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas