Homo sapiens Gene: TIAM1
Summary
InnateDB Gene IDBG-1597.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIAM1
Gene Name T-cell lymphoma invasion and metastasis 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000156299
Encoded Proteins
T-cell lymphoma invasion and metastasis 1
T-cell lymphoma invasion and metastasis 1
T-cell lymphoma invasion and metastasis 1
T-cell lymphoma invasion and metastasis 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 21:31118416-31559977
Strand Reverse strand
Band q22.11
Transcripts
ENST00000286827 ENSP00000286827
ENST00000423206 ENSP00000393384
ENST00000455508 ENSP00000388217
ENST00000491927
ENST00000469412
ENST00000541036 ENSP00000441570
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 40 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0046875 ephrin receptor binding
Biological Process
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0016477 cell migration
GO:0016601 Rac protein signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0043087 regulation of GTPase activity
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0050772 positive regulation of axonogenesis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0044291 cell-cell contact zone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (12/13) signalling events pathway
Developmental Biology pathway
Signalling by NGF pathway
EPHB-mediated forward signaling pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
Axon guidance pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
NRAGE signals death through JNK pathway
Rho GTPase cycle pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
KEGG
Chemokine signaling pathway pathway
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
PID NCI
E-cadherin signaling in the nascent adherens junction
Regulation of RAC1 activity
LPA receptor mediated events
Neurotrophic factor-mediated Trk receptor signaling
Ephrin B reverse signaling
CDC42 signaling events
Arf6 downstream pathway
EPHA2 forward signaling
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt Q13009
TrEMBL C9JMB5
UniProt Splice Variant
Entrez Gene 7074
UniGene Hs.517228 Hs.595209
RefSeq NM_003253 XM_005261037 XM_005261038 XM_005261039
HUGO HGNC:11805
OMIM 600687
CCDS CCDS13609
HPRD 02820
IMGT
EMBL AP000246 AP000247 AP000248 AP000249 AP000250 AP000251 AP000563 BC117192 BC117196 U16296
GenPept AAA98443 AAI17193 AAI17197
RNA Seq Atlas 102724932 7074