InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TIAM1

Summary

InnateDB Gene

IDBG-1597.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIAM1

Gene Name

T-cell lymphoma invasion and metastasis 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000156299

Encoded Proteins

IDBP-1599

T-cell lymphoma invasion and metastasis 1

IDBP-361857

T-cell lymphoma invasion and metastasis 1

IDBP-361858

T-cell lymphoma invasion and metastasis 1

IDBP-597056

T-cell lymphoma invasion and metastasis 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:31118416-31559977

Strand

Reverse strand

Band

q22.11

Transcripts

ENST00000286827	ENSP00000286827
ENST00000423206	ENSP00000393384
ENST00000455508	ENSP00000388217
ENST00000491927
ENST00000469412
ENST00000541036	ENSP00000441570

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	40 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0046875	ephrin receptor binding

Biological Process

GO:0007160	cell-matrix adhesion
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0016477	cell migration
GO:0016601	Rac protein signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043087	regulation of GTPase activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048013	ephrin receptor signaling pathway
GO:0050772	positive regulation of axonogenesis
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0044291	cell-cell contact zone