Mus musculus Gene: Mef2d
Summary
InnateDB Gene IDBG-159892.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mef2d
Gene Name myocyte enhancer factor 2D
Synonyms C80750;
Species Mus musculus
Ensembl Gene ENSMUSG00000001419
Encoded Proteins
myocyte enhancer factor 2D
myocyte enhancer factor 2D
myocyte enhancer factor 2D
myocyte enhancer factor 2D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116604:
This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:88142372-88172086
Strand Forward strand
Band F1
Transcripts
ENSMUST00000001455 ENSMUSP00000001455
ENSMUST00000107559 ENSMUSP00000103184
ENSMUST00000107558 ENSMUSP00000103183
ENSMUST00000119251 ENSMUSP00000113638
ENSMUST00000140927
ENSMUST00000139153
ENSMUST00000152861
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 7 [view]
Protein-DNA 3 [view]
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0033613 activating transcription factor binding
GO:0042803 protein homodimerization activity
GO:0042826 histone deacetylase binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0001649 osteoblast differentiation
GO:0001958 endochondral ossification
GO:0002062 chondrocyte differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0007399 nervous system development
GO:0007512 adult heart development
GO:0035914 skeletal muscle cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Developmental Biology pathway
Circadian Clock pathway
CDO in myogenesis pathway
Mitochondrial biogenesis pathway
Myogenesis pathway
Transcriptional activation of mitochondrial biogenesis pathway
KEGG
INOH
PID BIOCARTA
Regulation of pgc-1a [Biocarta view]
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
P38 mapk signaling pathway [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
Control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) [Biocarta view]
Mapkinase signaling pathway [Biocarta view]
Role of erk5 in neuronal survival pathway [Biocarta view]
Signal dependent regulation of myogenesis by corepressor mitr [Biocarta view]
PID NCI
Signaling events mediated by HDAC Class III
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.409911 Mm.485397
RefSeq NM_133665 XM_006501089 XM_006501091 XM_006501092
OMIM
CCDS CCDS38479
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas