Homo sapiens Gene: FBP1
Summary
InnateDB Gene IDBG-76936.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBP1
Gene Name fructose-1,6-bisphosphatase 1
Synonyms FBP;
Species Homo sapiens
Ensembl Gene ENSG00000165140
Encoded Proteins
fructose-1,6-bisphosphatase 1
fructose-1,6-bisphosphatase 1
fructose-1,6-bisphosphatase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:94603133-94640249
Strand Reverse strand
Band q22.32
Transcripts
ENST00000375326 ENSP00000364475
ENST00000415431 ENSP00000408025
ENST00000414122 ENSP00000411619
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016208 AMP binding
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0048029 monosaccharide binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006000 fructose metabolic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006111 regulation of gluconeogenesis
GO:0016311 dephosphorylation
GO:0030308 negative regulation of cell growth
GO:0035690 cellular response to drug
GO:0044281 small molecule metabolic process
GO:0045820 negative regulation of glycolytic process
GO:0046580 negative regulation of Ras protein signal transduction
GO:0046854 phosphatidylinositol phosphorylation
GO:0051289 protein homotetramerization
GO:0071286 cellular response to magnesium ion
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Gluconeogenesis pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Pentose phosphate pathway pathway
Fructose and mannose metabolism pathway
Insulin signaling pathway pathway
INOH
Pentose phosphate cycle pathway
Glycolysis Gluconeogenesis pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P09467
TrEMBL A8QID0 Q5VZC3
UniProt Splice Variant
Entrez Gene 2203
UniGene Hs.494496
RefSeq NM_000507 NM_001127628
HUGO HGNC:3606
OMIM 611570
CCDS CCDS6712
HPRD 01973
IMGT
EMBL AB003492 AF073475 AK223395 AL161728 AY866483 BC012927 D26054 D26055 D26056 L10320 M19922 U21925 U21926 U21927 U21929 U21930 U21931 U47918 U47919
GenPept AAA35517 AAA35817 AAA89097 AAA89098 AAC25774 AAC50207 AAH12927 AAW34363 BAA05051 BAA05052 BAA05053 BAD97115 BAF91908 CAH72692
RNA Seq Atlas 2203