InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FBP1

Summary

InnateDB Gene

IDBG-76936.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBP1

Gene Name

fructose-1,6-bisphosphatase 1

Synonyms

FBP

Species

Homo sapiens

Ensembl Gene

ENSG00000165140

Encoded Proteins

IDBP-76938

fructose-1,6-bisphosphatase 1

IDBP-375664

fructose-1,6-bisphosphatase 1

IDBP-375666

fructose-1,6-bisphosphatase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:94603133-94640249

Strand

Reverse strand

Band

q22.32

Transcripts

ENST00000375326	ENSP00000364475
ENST00000415431	ENSP00000408025
ENST00000414122	ENSP00000411619

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016208	AMP binding
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578	phosphoric ester hydrolase activity
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0048029	monosaccharide binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006000	fructose metabolic process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006111	regulation of gluconeogenesis
GO:0016311	dephosphorylation
GO:0030308	negative regulation of cell growth
GO:0035690	cellular response to drug
GO:0044281	small molecule metabolic process
GO:0045820	negative regulation of glycolytic process
GO:0046580	negative regulation of Ras protein signal transduction
GO:0046854	phosphatidylinositol phosphorylation
GO:0051289	protein homotetramerization
GO:0071286	cellular response to magnesium ion

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000069805

View Gene Order

ENSBTAG00000009733

Not yet available

Pathways

NETPATH

REACTOME

REACT_1520

Gluconeogenesis pathway

REACT_200783

Myoclonic epilepsy of Lafora pathway

REACT_474

Metabolism of carbohydrates pathway

REACT_111217

Metabolism pathway

REACT_116125

Disease pathway

REACT_723

Glucose metabolism pathway

REACT_200833

Glycogen storage diseases pathway

KEGG

hsa00010

Glycolysis / Gluconeogenesis pathway

hsa00030

Pentose phosphate pathway pathway

hsa04910

Insulin signaling pathway pathway

hsa00051

Fructose and mannose metabolism pathway

INOH

INOH website

Glycolysis Gluconeogenesis pathway

INOH website

Pentose phosphate cycle pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.494496

RefSeq

NM_000507 NM_001127628

HUGO

OMIM

CCDS

CCDS6712

HPRD

01973

IMGT

EMBL

GenPept

RNA Seq Atlas