Homo sapiens Gene: SOD1
Summary
InnateDB Gene IDBG-1609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOD1
Gene Name superoxide dismutase 1, soluble
Synonyms ALS; ALS1; HEL-S-44; homodimer; hSod1; IPOA; SOD;
Species Homo sapiens
Ensembl Gene ENSG00000142168
Encoded Proteins
superoxide dismutase 1, soluble
superoxide dismutase 1, soluble
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Sod1 is essential in protecting hepatocytes from virus-induced, interferon-driven oxidative damage in the liver.
Entrez Gene
Summary The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:31659622-31668931
Strand Forward strand
Band q22.11
Transcripts
ENST00000270142 ENSP00000270142
ENST00000389995 ENSP00000374645
ENST00000476106
ENST00000470944
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 84 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 84 [view]
Protein-Protein 76 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004784 superoxide dismutase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0030346 protein phosphatase 2B binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0048365 Rac GTPase binding
GO:0051087 chaperone binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0000302 response to reactive oxygen species
GO:0000303 response to superoxide
GO:0001541 ovarian follicle development
GO:0001819 positive regulation of cytokine production
GO:0001890 placenta development
GO:0001895 retina homeostasis
GO:0001975 response to amphetamine
GO:0002262 myeloid cell homeostasis
GO:0002576 platelet degranulation
GO:0006749 glutathione metabolic process
GO:0006801 superoxide metabolic process
GO:0006879 cellular iron ion homeostasis
GO:0006979 response to oxidative stress
GO:0007283 spermatogenesis
GO:0007566 embryo implantation
GO:0007568 aging
GO:0007569 cell aging
GO:0007596 blood coagulation
GO:0007605 sensory perception of sound
GO:0007626 locomotory behavior
GO:0008089 anterograde axon cargo transport
GO:0008090 retrograde axon cargo transport
GO:0008217 regulation of blood pressure
GO:0008219 cell death
GO:0009408 response to heat
GO:0010033 response to organic substance
GO:0019226 transmission of nerve impulse
GO:0019430 removal of superoxide radicals
GO:0030168 platelet activation
GO:0031667 response to nutrient levels
GO:0032287 peripheral nervous system myelin maintenance
GO:0032314 regulation of Rac GTPase activity
GO:0032930 positive regulation of superoxide anion generation
GO:0033081 regulation of T cell differentiation in thymus
GO:0034465 response to carbon monoxide
GO:0034599 cellular response to oxidative stress
GO:0035865 cellular response to potassium ion
GO:0040014 regulation of multicellular organism growth
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042554 superoxide anion generation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0045471 response to ethanol
GO:0045541 negative regulation of cholesterol biosynthetic process
GO:0045859 regulation of protein kinase activity
GO:0046620 regulation of organ growth
GO:0046677 response to antibiotic
GO:0046688 response to copper ion
GO:0046716 muscle cell cellular homeostasis
GO:0048538 thymus development
GO:0048678 response to axon injury
GO:0050665 hydrogen peroxide biosynthetic process
GO:0051881 regulation of mitochondrial membrane potential
GO:0055114 oxidation-reduction process
GO:0060047 heart contraction
GO:0060052 neurofilament cytoskeleton organization
GO:0060087 relaxation of vascular smooth muscle
GO:0060088 auditory receptor cell stereocilium organization
GO:0071276 cellular response to cadmium ion
GO:0071318 cellular response to ATP
GO:0072593 reactive oxygen species metabolic process
GO:0097332 response to antipsychotic drug
GO:1902177 positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030141 secretory granule
GO:0031012 extracellular matrix
GO:0031045 dense core granule
GO:0031410 cytoplasmic vesicle
GO:0032839 dendrite cytoplasm
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
IL1 pathway
REACTOME
Cellular responses to stress pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Detoxification of Reactive Oxygen Species pathway
Response to elevated platelet cytosolic Ca2+ pathway
Hemostasis pathway
KEGG
Peroxisome pathway
Amyotrophic lateral sclerosis (ALS) pathway
Huntington's disease pathway
Prion diseases pathway
INOH
PID BIOCARTA
Cardiac protection against ros [Biocarta view]
The igf-1 receptor and longevity [Biocarta view]
PID NCI
Validated nuclear estrogen receptor alpha network
FOXA1 transcription factor network
Cross-References
SwissProt P00441
TrEMBL H7BYH4 V9HWC9 W8Q444 X5D3G4 X5D5A9
UniProt Splice Variant
Entrez Gene 6647
UniGene
RefSeq NM_000454
HUGO HGNC:11179
OMIM 147450
CCDS CCDS33536
HPRD
IMGT
EMBL AK312116 AP000253 AP000254 AY049787 AY450286 AY835629 BC001034 BT006676 CH471079 CR450355 CR541742 EF151142 EU794661 KJ174530 KJ194105 KJ201029 L44135 L44136 L44137 L44139 L44746 L46374 L46375 X01780 X01781 X01782 X01783 X01784 X02317 X95228
GenPept AAB05661 AAB05662 AAB59626 AAB59627 AAC41773 AAH01034 AAL15444 AAP35322 AAR21563 AAV80422 ABL96616 ACJ13715 AHL39099 AHW49384 AHW49388 BAG35052 CAA25915 CAA25916 CAA25917 CAA25918 CAA25919 CAA26182 CAA64520 CAG29351 CAG46542 EAX09889 EAX09890
RNA Seq Atlas 6647