Mus musculus Gene: Hsd17b3
Summary
InnateDB Gene IDBG-161411.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hsd17b3
Gene Name hydroxysteroid (17-beta) dehydrogenase 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000033122
Encoded Proteins
hydroxysteroid (17-beta) dehydrogenase 3
hydroxysteroid (17-beta) dehydrogenase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130948:
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008]
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:64058274-64089201
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000039832 ENSMUSP00000044217
ENSMUST00000166224 ENSMUSP00000132011
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity
Biological Process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
GO:0061370 testosterone biosynthetic process
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Androgen biosynthesis pathway
Metabolism of steroid hormones and vitamin D pathway
KEGG
Steroid hormone biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Fatty Acyl-CoA Biosynthesis pathway
Metabolism of steroid hormones and vitamin D pathway
Triglyceride Biosynthesis pathway
Androgen biosynthesis pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Synthesis of very long-chain fatty acyl-CoAs pathway
KEGG
Steroid hormone biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.5109
RefSeq NM_008291
OMIM
CCDS CCDS26594
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas