Version 5.4
Mus musculus Gene: Pla2g6
Summary
InnateDB Gene IDBG-161414.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pla2g6
Gene Name phospholipase A2, group VI
Synonyms BB112799; iPLA(2)beta; iPLA2; iPLA2beta; PNPLA9
Species Mus musculus
Ensembl Gene ENSMUSG00000042632
Encoded Proteins
IDBP-161416
phospholipase A2, group VI
IDBP-620960
phospholipase A2, group VI
IDBP-620964
phospholipase A2, group VI
IDBP-620967
phospholipase A2, group VI
IDBP-620971
phospholipase A2, group VI
IDBP-620973
phospholipase A2, group VI
IDBP-620974
phospholipase A2, group VI
IDBP-620976
phospholipase A2, group VI
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184381:
The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:79286228-79328390
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000047816 ENSMUSP00000044234
ENSMUST00000174021 ENSMUSP00000134672
ENSMUST00000166977 ENSMUSP00000132071
ENSMUST00000173163 ENSMUSP00000134456
ENSMUST00000172403 ENSMUSP00000131081
ENSMUST00000174375
ENSMUST00000173412
ENSMUST00000173601
ENSMUST00000173632 ENSMUSP00000133998
ENSMUST00000174089
ENSMUST00000173109 ENSMUSP00000133554
ENSMUST00000172936 ENSMUSP00000133578
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0043008 ATP-dependent protein binding
GO:0047499 calcium-independent phospholipase A2 activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006629 lipid metabolic process
GO:0006935 chemotaxis
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007613 memory
GO:0008152 metabolic process
GO:0014832 urinary bladder smooth muscle contraction
GO:0016042 lipid catabolic process
GO:0032049 cardiolipin biosynthetic process
GO:0034976 response to endoplasmic reticulum stress
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045909 positive regulation of vasodilation
GO:0045921 positive regulation of exocytosis
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0060135 maternal process involved in female pregnancy
GO:0090037 positive regulation of protein kinase C signaling
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0090238 positive regulation of arachidonic acid secretion
GO:1901339 regulation of store-operated calcium channel activity
GO:2000304 positive regulation of ceramide biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000184381
View Gene Order
ENSBTAG00000014015
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_199038
Acyl chain remodelling of PC pathway
REACT_199034
Acyl chain remodeling of CL pathway
REACT_210240
Role of phospholipids in phagocytosis pathway
REACT_199027
Acyl chain remodelling of PE pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
mmu00564
Glycerophospholipid metabolism pathway
mmu00590
Arachidonic acid metabolism pathway
mmu00565
Ether lipid metabolism pathway
mmu00591
Linoleic acid metabolism pathway
mmu00592
alpha-Linolenic acid metabolism pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_120829
Acyl chain remodelling of PC pathway
REACT_121369
Acyl chain remodelling of PE pathway
REACT_121006
Acyl chain remodeling of CL pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6802
Innate Immune System pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_6900
Immune System pathway
REACT_120870
Phospholipid metabolism pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_111217
Metabolism pathway
KEGG
hsa00592
alpha-Linolenic acid metabolism pathway
hsa00590
Arachidonic acid metabolism pathway
hsa00564
Glycerophospholipid metabolism pathway
hsa00591
Linoleic acid metabolism pathway
hsa00565
Ether lipid metabolism pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.155620
RefSeq NM_001199023 NM_001199024 NM_001199025 NM_016915 XM_006521152 XM_006521153 XM_006521154 XM_006521155 XM_006521156 XM_006521157 XM_006521158 XM_006521159 XM_006521160
OMIM
CCDS CCDS27637 CCDS56991
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca