Homo sapiens Gene: UPP1
Summary
InnateDB Gene IDBG-16202.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UPP1
Gene Name uridine phosphorylase 1
Synonyms UDRPASE; UP; UPASE; UPP;
Species Homo sapiens
Ensembl Gene ENSG00000183696
Encoded Proteins
uridine phosphorylase 1
uridine phosphorylase 1
uridine phosphorylase 1
uridine phosphorylase 1
uridine phosphorylase 1
uridine phosphorylase 1
uridine phosphorylase 1
uridine phosphorylase 1
uridine phosphorylase 1
uridine phosphorylase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:48088628-48108733
Strand Forward strand
Band p12.3
Transcripts
ENST00000331803 ENSP00000330032
ENST00000395564 ENSP00000378931
ENST00000395560 ENSP00000378927
ENST00000416681 ENSP00000405209
ENST00000432131 ENSP00000387607
ENST00000457596 ENSP00000408899
ENST00000421046 ENSP00000414963
ENST00000436673 ENSP00000390118
ENST00000444999 ENSP00000396820
ENST00000417464 ENSP00000413611
ENST00000482015
ENST00000495446
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004850 uridine phosphorylase activity
GO:0016763 transferase activity, transferring pentosyl groups
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0009116 nucleoside metabolic process
GO:0009166 nucleotide catabolic process
GO:0042149 cellular response to glucose starvation
GO:0043097 pyrimidine nucleoside salvage
GO:0044206 UMP salvage
GO:0044281 small molecule metabolic process
GO:0046108 uridine metabolic process
GO:0046135 pyrimidine nucleoside catabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Pyrimidine catabolism pathway
Pyrimidine salvage reactions pathway
Pyrimidine metabolism pathway
Metabolism of nucleotides pathway
Metabolism pathway
KEGG
Pyrimidine metabolism pathway
Drug metabolism pathway
INOH
Pyrimidine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.488240
RefSeq NM_001287426 NM_001287428 NM_001287429 NM_003364
HUGO
OMIM
CCDS CCDS5507
HPRD 08932
IMGT
EMBL
GenPept
RNA Seq Atlas