Mus musculus Gene: Idh1
Summary
InnateDB Gene IDBG-162070.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Idh1
Gene Name isocitrate dehydrogenase 1 (NADP+), soluble
Synonyms AI314845; AI788952; E030024J03Rik; Id-1; Idh-1; Idpc;
Species Mus musculus
Ensembl Gene ENSMUSG00000025950
Encoded Proteins
isocitrate dehydrogenase 1 (NADP+), soluble
isocitrate dehydrogenase 1 (NADP+), soluble
isocitrate dehydrogenase 1 (NADP+), soluble
isocitrate dehydrogenase 1 (NADP+), soluble
isocitrate dehydrogenase 1 (NADP+), soluble
isocitrate dehydrogenase 1 (NADP+), soluble
isocitrate dehydrogenase 1 (NADP+), soluble
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138413:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq, Jul 2008]
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:65158616-65186500
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000097709 ENSMUSP00000095316
ENSMUST00000149310 ENSMUSP00000117853
ENSMUST00000169032 ENSMUSP00000127307
ENSMUST00000188109 ENSMUSP00000140757
ENSMUST00000188876 ENSMUSP00000139906
ENSMUST00000186222 ENSMUSP00000140694
ENSMUST00000191459 ENSMUSP00000139430
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004450 isocitrate dehydrogenase (NADP+) activity
GO:0005102 receptor binding
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803 protein homodimerization activity
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0006102 isocitrate metabolic process
GO:0006103 2-oxoglutarate metabolic process
GO:0006749 glutathione metabolic process
GO:0006979 response to oxidative stress
GO:0008585 female gonad development
GO:0014070 response to organic cyclic compound
GO:0048545 response to steroid hormone
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Disease pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
NADPH regeneration pathway
Peroxisomal lipid metabolism pathway
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate pathway
KEGG
Citrate cycle (TCA cycle) pathway
Glutathione metabolism pathway
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate pathway
Peroxisomal lipid metabolism pathway
NADPH regeneration pathway
Metabolism pathway
Disease pathway
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate pathway
Metabolism of lipids and lipoproteins pathway
NADPH regeneration pathway
Metabolism pathway
Peroxisomal lipid metabolism pathway
Disease pathway
KEGG
Citrate cycle (TCA cycle) pathway
Glutathione metabolism pathway
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt O88844
TrEMBL D3YVY3
UniProt Splice Variant
Entrez Gene 15926
UniGene Mm.9925
RefSeq NM_001111320 NM_010497
OMIM
CCDS CCDS15016
HPRD
IMGT
MGI ID MGI:96413
MGI Symbol Idh1
EMBL AC101869 AC164079 AF020039 AK149019 AK151212 AK159173 AK160896 AK167158 CH466548
GenPept AAD02919 BAE28720 BAE30207 BAE34873 BAE36075 BAE39299 EDL00223 EDL00225
RNA Seq Atlas 15926