Mus musculus Gene: Ldb2
Summary
InnateDB Gene IDBG-162180.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ldb2
Gene Name LIM domain binding 2
Synonyms AI035351; AW146358; CLIM1; CLP-36; Ldb3;
Species Mus musculus
Ensembl Gene ENSMUSG00000039706
Encoded Proteins
LIM domain binding 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169744:
Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins (summarized by Semina et al., 1998 [PubMed 9799849]). These proteins, such as the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes (Jurata and Gill, 1997 [PubMed 9315627]). The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse, Clim1 (Bach et al., 1997 [PubMed 9192866]) and Clim2/Lbd1/Nli (Agulnick et al., 1996 [PubMed 8918878]; Jurata et al., 1996 [PubMed 8876198]; Bach et al., 1997 [PubMed 9192866]) and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:44472133-44799707
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000070748 ENSMUSP00000067737
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000989 transcription factor binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0030274 LIM domain binding
Biological Process
GO:0001942 hair follicle development
GO:0010669 epithelial structure maintenance
GO:0035019 somatic stem cell maintenance
GO:0044089 positive regulation of cellular component biogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt O55203
TrEMBL
UniProt Splice Variant
Entrez Gene 16826
UniGene Mm.402732 Mm.466356
RefSeq NM_001077398 NM_010698 XM_006503752 XM_006503753
OMIM
CCDS CCDS19271
HPRD
IMGT
MGI ID MGI:894670
MGI Symbol Ldb2
EMBL AK146860 AK147160 BC079611 U89487 U89489
GenPept AAB96884 AAB96886 AAH79611 BAE27488 BAE27725
RNA Seq Atlas 16826