InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ldb2

Summary

InnateDB Gene

IDBG-162180.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ldb2

Gene Name

LIM domain binding 2

Synonyms

AI035351; AW146358; CLIM1; CLP-36; Ldb3;

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039706

Encoded Proteins

IDBP-162182

LIM domain binding 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169744:
Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins (summarized by Semina et al., 1998 [PubMed 9799849]). These proteins, such as the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes (Jurata and Gill, 1997 [PubMed 9315627]). The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse, Clim1 (Bach et al., 1997 [PubMed 9192866]) and Clim2/Lbd1/Nli (Agulnick et al., 1996 [PubMed 8918878]; Jurata et al., 1996 [PubMed 8876198]; Bach et al., 1997 [PubMed 9192866]) and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.[supplied by OMIM, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:44472133-44799707

Strand

Reverse strand

Band

Transcripts

ENSMUST00000070748

ENSMUSP00000067737

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000989	transcription factor binding transcription factor activity
GO:0003712	transcription cofactor activity
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0030274	LIM domain binding

Biological Process

GO:0001942	hair follicle development
GO:0010669	epithelial structure maintenance
GO:0035019	somatic stem cell maintenance
GO:0044089	positive regulation of cellular component biogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSG00000169744

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000014058

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Cross-References

SwissProt

O55203

TrEMBL

UniProt Splice Variant

Entrez Gene

16826

UniGene

Mm.402732 Mm.466356

RefSeq

NM_001077398 NM_010698 XM_006503752 XM_006503753

OMIM

CCDS

CCDS19271

HPRD

IMGT

MGI ID

MGI:894670

MGI Symbol

Ldb2

EMBL

AK146860 AK147160 BC079611 U89487 U89489

GenPept

AAB96884 AAB96886 AAH79611 BAE27488 BAE27725

RNA Seq Atlas

16826