Version 5.4
Bos taurus Gene: LDB2
Summary
InnateDB Gene IDBG-644013.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LDB2
Gene Name LIM domain binding 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014058
Encoded Proteins
IDBP-696619
LIM domain binding 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169744:
Genes encoding LIM domain-binding factors were initially isolated in a screen for proteins that physically interact with the LIM domains of nuclear proteins (summarized by Semina et al., 1998 [PubMed 9799849]). These proteins, such as the one encoded by the LDB2 gene, are capable of binding to a variety of transcription factors and are likely to function at enhancers to bring together diverse transcription factors and form higher order activation complexes or to block formation of such complexes (Jurata and Gill, 1997 [PubMed 9315627]). The family of genes encoding LIM domain-binding factors includes 2 members isolated from the mouse, Clim1 (Bach et al., 1997 [PubMed 9192866]) and Clim2/Lbd1/Nli (Agulnick et al., 1996 [PubMed 8918878]; Jurata et al., 1996 [PubMed 8876198]; Bach et al., 1997 [PubMed 9192866]) and their homologs cloned from the frog, chicken, and fly. The fact that LIM domain-binding factors are likely to be involved in the coordination of the transcriptional activity of many diverse factors might implicate them in human phenotypes characterized by multiple affected sites.[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:116534190-116998914
Strand Reverse strand
Band
Transcripts
ENSBTAT00000018687 ENSBTAP00000018687
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000989 transcription factor binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0030274 LIM domain binding
Biological Process
GO:0001942 hair follicle development
GO:0010669 epithelial structure maintenance
GO:0035019 somatic stem cell maintenance
GO:0044089 positive regulation of cellular component biogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000169744
View Gene Order
ENSMUSG00000039706
View Gene Order
Cross-References
SwissProt
TrEMBL F6R129
UniProt Splice Variant
Entrez Gene 617976
UniGene Bt.11446
RefSeq NM_001046611 XM_005208317 XM_005208318 XM_005208319
HUGO HGNC:6533
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02018776 DAAA02018777 DAAA02018778 DAAA02018779 DAAA02018780 DAAA02018781 DAAA02018782 DAAA02018783 DAAA02018784 DAAA02018785 DAAA02018786 DAAA02018787 DAAA02018788 DAAA02018789 DAAA02018790 DAAA02018791 DAAA02018792
GenPept
RNA Seq Atlas 617976

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca