Version 5.4
Mus musculus Gene: Slit3
Summary
InnateDB Gene IDBG-162473.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slit3
Gene Name slit homolog 3 (Drosophila)
Synonyms Slil2; Slit1
Species Mus musculus
Ensembl Gene ENSMUSG00000056427
Encoded Proteins
IDBP-162475
slit homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000184347:
The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:35121224-35708507
Strand Forward strand
Band A4
Transcripts
ENSMUST00000069837 ENSMUSP00000066857
ENSMUST00000156571
ENSMUST00000153098
ENSMUST00000124438
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0048495 Roundabout binding
Biological Process
GO:0007411 axon guidance
GO:0008285 negative regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0010629 negative regulation of gene expression
GO:0030308 negative regulation of cell growth
GO:0032870 cellular response to hormone stimulus
GO:0035385 Roundabout signaling pathway
GO:0048846 axon extension involved in axon guidance
GO:0050919 negative chemotaxis
GO:0051414 response to cortisol
GO:0061364 apoptotic process involved in luteolysis
GO:0070100 negative regulation of chemokine-mediated signaling pathway
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000184347
View Gene Order
ENSBTAG00000017746
Not yet available
Pathways
NETPATH
REACTOME
REACT_229826
Netrin-1 signaling pathway
REACT_261444
Axon guidance pathway
REACT_188576
Developmental Biology pathway
KEGG
mmu04360
Axon guidance pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.478604
RefSeq NM_011412
OMIM
CCDS CCDS24542
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca