Homo sapiens Gene: SLIT3
Summary
InnateDB Gene IDBG-56989.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLIT3
Gene Name slit homolog 3 (Drosophila)
Synonyms MEGF5; SLIL2; Slit-3; SLIT1; slit2;
Species Homo sapiens
Ensembl Gene ENSG00000184347
Encoded Proteins
slit homolog 3 (Drosophila)
slit homolog 3 (Drosophila)
slit homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:168661733-169301129
Strand Reverse strand
Band q35.1
Transcripts
ENST00000332966 ENSP00000332164
ENST00000404867 ENSP00000384890
ENST00000519560 ENSP00000430333
ENST00000518092
ENST00000519486
ENST00000518140
ENST00000521150
ENST00000521130
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0048495 Roundabout binding
Biological Process
GO:0007411 axon guidance
GO:0008285 negative regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0010629 negative regulation of gene expression
GO:0030308 negative regulation of cell growth
GO:0032870 cellular response to hormone stimulus
GO:0035385 Roundabout signaling pathway
GO:0048846 axon extension involved in axon guidance
GO:0050919 negative chemotaxis
GO:0051414 response to cortisol
GO:0061364 apoptotic process involved in luteolysis
GO:0070100 negative regulation of chemokine-mediated signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Axon guidance pathway
Netrin-1 signaling pathway
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.552087 Hs.604116
RefSeq NM_001271946 NM_003062
HUGO
OMIM
CCDS CCDS4369 CCDS64311
HPRD 04775
IMGT
EMBL
GenPept
RNA Seq Atlas