Version 5.4
Homo sapiens Gene: SLIT3
Summary
InnateDB Gene IDBG-56989.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLIT3
Gene Name slit homolog 3 (Drosophila)
Synonyms MEGF5; SLIL2; Slit-3; SLIT1; slit2
Species Homo sapiens
Ensembl Gene ENSG00000184347
Encoded Proteins
IDBP-56991
slit homolog 3 (Drosophila)
IDBP-295138
slit homolog 3 (Drosophila)
IDBP-482369
slit homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:168661733-169301129
Strand Reverse strand
Band q35.1
Transcripts
ENST00000332966 ENSP00000332164
ENST00000404867 ENSP00000384890
ENST00000519560 ENSP00000430333
ENST00000518092
ENST00000519486
ENST00000518140
ENST00000521150
ENST00000521130
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0048495 Roundabout binding
Biological Process
GO:0007411 axon guidance
GO:0008285 negative regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0010629 negative regulation of gene expression
GO:0030308 negative regulation of cell growth
GO:0032870 cellular response to hormone stimulus
GO:0035385 Roundabout signaling pathway
GO:0048846 axon extension involved in axon guidance
GO:0050919 negative chemotaxis
GO:0051414 response to cortisol
GO:0061364 apoptotic process involved in luteolysis
GO:0070100 negative regulation of chemokine-mediated signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000056427
View Gene Order
ENSBTAG00000017746
Not yet available
Pathways
NETPATH
REACTOME
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.552087 Hs.604116
RefSeq NM_001271946 NM_003062
HUGO
OMIM
CCDS CCDS4369 CCDS64311
HPRD 04775
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca