Mus musculus Gene: Hook1
Summary
InnateDB Gene IDBG-164401.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hook1
Gene Name hook homolog 1 (Drosophila)
Synonyms A930033L17Rik; azh;
Species Mus musculus
Ensembl Gene ENSMUSG00000028572
Encoded Proteins
hook homolog 1 (Drosophila)
hook homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134709:
This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:95967240-96025413
Strand Forward strand
Band C5
Transcripts
ENSMUST00000030306 ENSMUSP00000030306
ENSMUST00000107083 ENSMUSP00000102698
ENSMUST00000125627
ENSMUST00000141448
ENSMUST00000146947
ENSMUST00000124202
ENSMUST00000148291
ENSMUST00000143326
ENSMUST00000125584
ENSMUST00000140128
ENSMUST00000156910
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0042802 identical protein binding
Biological Process
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0007275 multicellular organismal development
GO:0007286 spermatid development
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0045022 early endosome to late endosome transport
Cellular Component
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
GO:0030897 HOPS complex
GO:0070695 FHF complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.393290 Mm.446706 Mm.49994
RefSeq NM_030014 XM_006503487 XM_006503488
OMIM
CCDS CCDS18367
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas