Version 5.4
Bos taurus Gene: HOOK1
Summary
InnateDB Gene IDBG-638782.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOOK1
Gene Name protein Hook homolog 1
Synonyms HOOK1
Species Bos taurus
Ensembl Gene ENSBTAG00000030671
Encoded Proteins
IDBP-690935
hook homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134709:
This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:86650798-86718972
Strand Reverse strand
Band
Transcripts
ENSBTAT00000033420 ENSBTAP00000033333
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0007286 spermatid development
GO:0008333 endosome to lysosome transport
GO:0045022 early endosome to late endosome transport
Cellular Component
GO:0015630 microtubule cytoskeleton
GO:0030897 HOPS complex
GO:0070695 FHF complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000134709
View Gene Order
ENSMUSG00000028572
View Gene Order
Cross-References
SwissProt
TrEMBL E1BAT1
UniProt Splice Variant
Entrez Gene 785042
UniGene Bt.104356 Bt.59065
RefSeq NM_001206870 XM_005204526
HUGO HGNC:19884
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02008735
GenPept
RNA Seq Atlas 785042

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca