Mus musculus Gene: Pgk1
Summary
InnateDB Gene IDBG-166967.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pgk1
Gene Name phosphoglycerate kinase 1
Synonyms Pgk-1;
Species Mus musculus
Ensembl Gene ENSMUSG00000062070
Encoded Proteins
phosphoglycerate kinase 1
phosphoglycerate kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Many pseudogenes of this gene are found throughout the mouse genome. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome X:106187100-106203699
Strand Forward strand
Band D
Transcripts
ENSMUST00000081593 ENSMUSP00000080302
ENSMUST00000135949 ENSMUSP00000138706
ENSMUST00000133559
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004618 phosphoglycerate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Disease pathway
Glycolysis pathway
Glucose metabolism pathway
Metabolism pathway
Gluconeogenesis pathway
Glycogen storage diseases pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
KEGG
Glycolysis / Gluconeogenesis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Gluconeogenesis pathway
Glycolysis pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
Metabolism of carbohydrates pathway
Myoclonic epilepsy of Lafora pathway
Gluconeogenesis pathway
Glycogen storage diseases pathway
Glucose metabolism pathway
Metabolism pathway
Glycolysis pathway
Disease pathway
KEGG
Glycolysis / Gluconeogenesis pathway
INOH
Glycolysis Gluconeogenesis pathway
PID BIOCARTA
PID NCI
HIF-2-alpha transcription factor network
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL B0LAA9 S4R2M7
UniProt Splice Variant
Entrez Gene 18655
UniGene
RefSeq NM_008828
OMIM
CCDS CCDS30339
HPRD
IMGT
MGI ID MGI:97555
MGI Symbol Pgk1
EMBL BX469914 EF437325
GenPept ABS83503
RNA Seq Atlas 18655