Bos taurus Gene: PGK1
Summary
InnateDB Gene IDBG-635263.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PGK1
Gene Name Phosphoglycerate kinase 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000894
Encoded Proteins
Phosphoglycerate kinase 1
Phosphoglycerate kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102144:
The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. This gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19. [provided by RefSeq, Oct 2008]
The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. Additionally, this protein is secreted by tumor cells where it participates in angiogenesis by functioning to reduce disulfide bonds in the serine protease, plasmin, which consequently leads to the release of the tumor blood vessel inhibitor angiostatin. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Deficiency of the enzyme is associated with a wide range of clinical phenotypes hemolytic anemia and neurological impairment. Pseudogenes of this gene have been defined on chromosomes 19, 21 and the X chromosome. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome X:79282708-79305386
Strand Reverse strand
Band
Transcripts
ENSBTAT00000001187 ENSBTAP00000001187
ENSBTAT00000039206 ENSBTAP00000039006
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004618 phosphoglycerate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
Biological Process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0030855 epithelial cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Metabolism of carbohydrates pathway
Myoclonic epilepsy of Lafora pathway
Gluconeogenesis pathway
Glycogen storage diseases pathway
Glucose metabolism pathway
Metabolism pathway
Glycolysis pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Gluconeogenesis pathway
Glycolysis pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
Disease pathway
Glycolysis pathway
Glucose metabolism pathway
Metabolism pathway
Gluconeogenesis pathway
Glycogen storage diseases pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Glycolysis / Gluconeogenesis pathway
INOH
Glycolysis Gluconeogenesis pathway
PID BIOCARTA
PID NCI
HIF-2-alpha transcription factor network
HIF-1-alpha transcription factor network
Cross-References
SwissProt Q3T0P6
TrEMBL Q9GK71
UniProt Splice Variant
Entrez Gene 507476
UniGene Bt.37560
RefSeq NM_001034299
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF304436 BC102308
GenPept AAG42238 AAI02309
RNA Seq Atlas 507476
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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