InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adarb1

Summary

InnateDB Gene

IDBG-166979.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adarb1

Gene Name

adenosine deaminase, RNA-specific, B1

Synonyms

1700057H01Rik; Adar2; AW124433; AW558573; BB220382; D10Bwg0447e; Red1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020262

Encoded Proteins

IDBP-166981

adenosine deaminase, RNA-specific, B1

IDBP-192736

adenosine deaminase, RNA-specific, B1

IDBP-270946

adenosine deaminase, RNA-specific, B1

IDBP-270950

adenosine deaminase, RNA-specific, B1

IDBP-532012

adenosine deaminase, RNA-specific, B1

IDBP-534504

adenosine deaminase, RNA-specific, B1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:77290726-77418270

Strand

Reverse strand

Band

Transcripts

ENSMUST00000020496	ENSMUSP00000020496
ENSMUST00000098374	ENSMUSP00000095976
ENSMUST00000105406	ENSMUSP00000101046
ENSMUST00000105404	ENSMUSP00000101044
ENSMUST00000144547	ENSMUSP00000122102
ENSMUST00000126073	ENSMUSP00000114608
ENSMUST00000149738
ENSMUST00000154607
ENSMUST00000150227
ENSMUST00000150512
ENSMUST00000156583
ENSMUST00000146319
ENSMUST00000155117

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0003726	double-stranded RNA adenosine deaminase activity
GO:0004000	adenosine deaminase activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006382	adenosine to inosine editing
GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0008285	negative regulation of cell proliferation
GO:0030336	negative regulation of cell migration
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045070	positive regulation of viral genome replication
GO:0051726	regulation of cell cycle