InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ADARB1

Summary

InnateDB Gene

IDBG-639626.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADARB1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017486

Encoded Proteins

IDBP-691824

adenosine deaminase, RNA-specific, B1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197381:
This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:145518051-145555780

Strand

Forward strand

Band

Transcripts

ENSBTAT00000023240

ENSBTAP00000023240

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0003726	double-stranded RNA adenosine deaminase activity
GO:0004000	adenosine deaminase activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006382	adenosine to inosine editing
GO:0006396	RNA processing
GO:0008285	negative regulation of cell proliferation
GO:0030336	negative regulation of cell migration
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045070	positive regulation of viral genome replication
GO:0051726	regulation of cell cycle