InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADARB1

Summary

InnateDB Gene

IDBG-5701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADARB1

Gene Name

adenosine deaminase, RNA-specific, B1

Synonyms

ADAR2; DRABA2; DRADA2; RED1

Species

Homo sapiens

Ensembl Gene

ENSG00000197381

Encoded Proteins

IDBP-5703

adenosine deaminase, RNA-specific, B1

IDBP-5705

adenosine deaminase, RNA-specific, B1

IDBP-5711

adenosine deaminase, RNA-specific, B1

IDBP-5715

adenosine deaminase, RNA-specific, B1

IDBP-370817

adenosine deaminase, RNA-specific, B1

IDBP-370818

adenosine deaminase, RNA-specific, B1

IDBP-583333

adenosine deaminase, RNA-specific, B1

IDBP-589463

adenosine deaminase, RNA-specific, B1

IDBP-813164

adenosine deaminase, RNA-specific, B1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:45073853-45226560

Strand

Forward strand

Band

q22.3

Transcripts

ENST00000360697	ENSP00000353920
ENST00000348831	ENSP00000015877
ENST00000389863	ENSP00000374513
ENST00000389861	ENSP00000374511
ENST00000437626	ENSP00000414600
ENST00000449478	ENSP00000387480
ENST00000462214
ENST00000460734
ENST00000492414	ENSP00000436367
ENST00000496664	ENSP00000435381
ENST00000464215
ENST00000481022
ENST00000611195	ENSP00000478160

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0003726	double-stranded RNA adenosine deaminase activity
GO:0003729	mRNA binding
GO:0004000	adenosine deaminase activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006382	adenosine to inosine editing
GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0008285	negative regulation of cell proliferation
GO:0010467	gene expression
GO:0016553	base conversion or substitution editing
GO:0016556	mRNA modification
GO:0030336	negative regulation of cell migration
GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045070	positive regulation of viral genome replication
GO:0045087	innate immune response
GO:0051607	defense response to virus
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020262

View Gene Order

ENSBTAG00000017486

Not yet available

Pathways

NETPATH

REACTOME

REACT_1231

C6 deamination of adenosine pathway

REACT_1966

Formation of editosomes by ADAR proteins pathway

REACT_1757

mRNA Editing pathway

REACT_71

Gene Expression pathway

REACT_18

mRNA Editing: A to I Conversion pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q8TCX7

UniProt Splice Variant

Entrez Gene

104

UniGene

RefSeq

NM_001112 NM_001160230 NM_015833 NM_015834 XM_006723953 XM_006723954 XM_006723955 XM_006723956 XM_006723957

HUGO

HGNC:226

OMIM

601218

CCDS

CCDS33589 CCDS33590 CCDS42970

HPRD

IMGT

EMBL

AY082339 CH471079

GenPept

AAL99252 EAX09362

RNA Seq Atlas

104