Version 5.4
Mus musculus Gene: Plcd4
Summary
InnateDB Gene IDBG-167412.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plcd4
Gene Name phospholipase C, delta 4
Synonyms 4921507K24Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000026173
Encoded Proteins
IDBP-167414
phospholipase C, delta 4
IDBP-167416
phospholipase C, delta 4
IDBP-253211
phospholipase C, delta 4
IDBP-253213
phospholipase C, delta 4
IDBP-253217
phospholipase C, delta 4
IDBP-540851
phospholipase C, delta 4
IDBP-533153
phospholipase C, delta 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115556:
This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:74542888-74567794
Strand Forward strand
Band C3
Transcripts
ENSMUST00000067916 ENSMUSP00000064413
ENSMUST00000027362 ENSMUSP00000027362
ENSMUST00000113750 ENSMUSP00000109379
ENSMUST00000113749 ENSMUSP00000109378
ENSMUST00000113747 ENSMUSP00000109376
ENSMUST00000113745
ENSMUST00000141412 ENSMUSP00000115322
ENSMUST00000152707 ENSMUSP00000121732
ENSMUST00000135111
ENSMUST00000185411
ENSMUST00000189956
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0007340 acrosome reaction
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0046488 phosphatidylinositol metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115556
View Gene Order
ENSBTAG00000003809
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04070
Phosphatidylinositol signaling system pathway
mmu00562
Inositol phosphate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04020
Calcium signaling pathway pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.290731 Mm.401433
RefSeq NM_001081456 NM_148937 XM_006495788
OMIM
CCDS CCDS35616 CCDS35617
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca