InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Erap1

Summary

InnateDB Gene

IDBG-167595.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Erap1

Gene Name

endoplasmic reticulum aminopeptidase 1

Synonyms

Arts1; ERAAP; PILSA; PILSAP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021583

Encoded Proteins

IDBP-626781

endoplasmic reticulum aminopeptidase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18445477

[Homo sapiens] ERAP1 associates with RBMX and a heterogeneous nuclear ribonucleoprotein to regulate both the constitutive release of TNFR1 exosome-like vesicles and the inducible proteolytic cleavage of TNFR1 ectodomains.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164307:
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:74639872-74691875

Strand

Forward strand

Band

Transcripts

ENSMUST00000169114

ENSMUSP00000133166

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0005138	interleukin-6 receptor binding
GO:0005515	protein binding
GO:0008235	metalloexopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0002376	immune system process
GO:0006509	membrane protein ectodomain proteolysis
GO:0009617	response to bacterium
GO:0045766	positive regulation of angiogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000164307

View Gene Order

ENSBTAG00000013557

Not yet available

Pathways

NETPATH

REACTOME

REACT_236645

Class I MHC mediated antigen processing & presentation pathway

REACT_230745

Immune System pathway

REACT_229531

Adaptive Immune System pathway

REACT_246972

Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75795

Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.83526

RefSeq

NM_030711 XM_006517476

OMIM

CCDS

CCDS26647

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas