InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.28338

Summary

InnateDB Gene

IDBG-646590.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.28338

Gene Name

endoplasmic reticulum aminopeptidase 1 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013557

Encoded Proteins

IDBP-699411

endoplasmic reticulum aminopeptidase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18445477

[Homo sapiens] ERAP1 associates with RBMX and a heterogeneous nuclear ribonucleoprotein to regulate both the constitutive release of TNFR1 exosome-like vesicles and the inducible proteolytic cleavage of TNFR1 ectodomains.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164307:
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:98582890-98618194

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000018026

ENSBTAP00000018026

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0005138	interleukin-6 receptor binding
GO:0005515	protein binding
GO:0008235	metalloexopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding