InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: H2-DMb2

Summary

InnateDB Gene

IDBG-170493.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2-DMb2

Gene Name

histocompatibility 2, class II, locus Mb2

Synonyms

H-2Mb2; H2-Mb2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037548

Encoded Proteins

IDBP-170495

histocompatibility 2, class II, locus Mb2

IDBP-627064

histocompatibility 2, class II, locus Mb2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000242574:
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34143307-34151553

Strand

Forward strand

Band

Transcripts

ENSMUST00000041982	ENSMUSP00000043526
ENSMUST00000173262
ENSMUST00000171231	ENSMUSP00000126533

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0051085	chaperone mediated protein folding requiring cofactor

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042613	MHC class II protein complex