Mus musculus Gene: H2-Ob | |||||||||||
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Summary | |||||||||||
InnateDB Gene | IDBG-170825.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | H2-Ob | ||||||||||
Gene Name | histocompatibility 2, O region beta locus | ||||||||||
Synonyms | A-beta-2; A-beta2; H-2Ab; H-2I; H-2Ob; H2-Ab; H2-Ab2; H2-IAb2; Ob | ||||||||||
Species | Mus musculus | ||||||||||
Ensembl Gene | ENSMUSG00000041538 | ||||||||||
Encoded Proteins |
histocompatibility 2, O region beta locus
histocompatibility 2, O region beta locus
histocompatibility 2, O region beta locus
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Protein Structure | |||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
Entrez Gene | |||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000241106:
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||
Type | Protein coding | ||||||||||
Genomic Location | Chromosome 17:34238903-34245907 | ||||||||||
Strand | Forward strand | ||||||||||
Band | B1 | ||||||||||
Transcripts |
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Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||
NETPATH | |||||||||||
REACTOME | |||||||||||
KEGG |
Cell adhesion molecules (CAMs) pathway
Type I diabetes mellitus pathway
Antigen processing and presentation pathway
Asthma pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Systemic lupus erythematosus pathway
Autoimmune thyroid disease pathway
Intestinal immune network for IgA production pathway
Viral myocarditis pathway
Staphylococcus aureus infection pathway
Leishmaniasis pathway
Phagosome pathway
Toxoplasmosis pathway
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INOH | |||||||||||
PID NCI | |||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||
NETPATH | |||||||||||
REACTOME |
MHC class II antigen presentation pathway
Adaptive Immune System pathway
Immune System pathway
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KEGG |
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Type I diabetes mellitus pathway
Allograft rejection pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Graft-versus-host disease pathway
Asthma pathway
Intestinal immune network for IgA production pathway
Viral myocarditis pathway
Leishmaniasis pathway
Staphylococcus aureus infection pathway
Toxoplasmosis pathway
Phagosome pathway
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INOH | |||||||||||
PID NCI | |||||||||||
Cross-References | |||||||||||
SwissProt | |||||||||||
TrEMBL | G3UY15 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 15002 | ||||||||||
UniGene | Mm.327358 | ||||||||||
RefSeq | NM_010389 XM_006523685 XM_006525315 XM_006536529 XM_006537262 | ||||||||||
OMIM | |||||||||||
CCDS | CCDS37582 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
MGI ID | MGI:95925 | ||||||||||
MGI Symbol | H2-Ob | ||||||||||
EMBL | CR974422 | ||||||||||
GenPept | |||||||||||
RNA Seq Atlas | 15002 | ||||||||||