InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BOLA-DOB

Summary

InnateDB Gene

IDBG-628816.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BOLA-DOB

Gene Name

HLA class II histocompatibility antigen, DO beta chain precursor

Synonyms

DOB

Species

Bos taurus

Ensembl Gene

ENSBTAG00000047707

Encoded Proteins

IDBP-680201

major histocompatibility complex, class II, DO beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000241106:
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:7054419-7063641

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000065976

ENSBTAP00000055511

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0023026	MHC class II protein complex binding

Biological Process

GO:0002376	immune system process
GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002587	negative regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0006955	immune response
GO:0019882	antigen processing and presentation