InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HLA-DOB

Summary

InnateDB Gene

IDBG-403007.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HLA-DOB

Gene Name

major histocompatibility complex, class II, DO beta

Synonyms

DOB

Species

Homo sapiens

Ensembl Gene

ENSG00000241106

Encoded Proteins

IDBP-374637

major histocompatibility complex, class II, DO beta

IDBP-374648

major histocompatibility complex, class II, DO beta

IDBP-597696

major histocompatibility complex, class II, DO beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:32812763-32817048

Strand

Reverse strand

Band

p21.32

Transcripts

ENST00000438763	ENSP00000390020
ENST00000447394	ENSP00000394860
ENST00000488325	ENSP00000436618
ENST00000475235

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0023026	MHC class II protein complex binding
GO:0032395	MHC class II receptor activity

Biological Process

GO:0002587	negative regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0006955	immune response
GO:0007165	signal transduction
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

Cellular Component

GO:0005622	intracellular
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042613	MHC class II protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000041538

View Gene Order

ENSBTAG00000047707

Not yet available

Pathways

NETPATH

REACTOME

REACT_121399

MHC class II antigen presentation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

hsa04612

Antigen processing and presentation pathway

hsa04940

Type I diabetes mellitus pathway

hsa05330

Allograft rejection pathway

hsa05320

Autoimmune thyroid disease pathway

hsa05322

Systemic lupus erythematosus pathway

hsa05332

Graft-versus-host disease pathway

hsa05310

Asthma pathway

hsa04672

Intestinal immune network for IgA production pathway

hsa05416

Viral myocarditis pathway

hsa05140

Leishmaniasis pathway

hsa05150

Staphylococcus aureus infection pathway

hsa05145

Toxoplasmosis pathway

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.1802

RefSeq

NM_002120

HUGO

OMIM

CCDS

CCDS4754

HPRD

08368

IMGT

EMBL

GenPept

RNA Seq Atlas