Homo sapiens Gene: HLA-DOB
Summary
InnateDB Gene IDBG-403007.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HLA-DOB
Gene Name major histocompatibility complex, class II, DO beta
Synonyms DOB;
Species Homo sapiens
Ensembl Gene ENSG00000241106
Encoded Proteins
major histocompatibility complex, class II, DO beta
major histocompatibility complex, class II, DO beta
major histocompatibility complex, class II, DO beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32812763-32817048
Strand Reverse strand
Band p21.32
Transcripts
ENST00000438763 ENSP00000390020
ENST00000447394 ENSP00000394860
ENST00000488325 ENSP00000436618
ENST00000475235
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0023026 MHC class II protein complex binding
GO:0032395 MHC class II receptor activity
Biological Process
GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0006955 immune response
GO:0007165 signal transduction
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0005622 intracellular
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042613 MHC class II protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
MHC class II antigen presentation pathway
Adaptive Immune System pathway
Immune System pathway
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Leishmaniasis pathway
Toxoplasmosis pathway
Staphylococcus aureus infection pathway
Asthma pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.1802
RefSeq NM_002120
HUGO
OMIM
CCDS CCDS4754
HPRD 08368
IMGT
EMBL
GenPept
RNA Seq Atlas