Mus musculus Gene: H2-Eb1
Summary
InnateDB Gene IDBG-171115.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H2-Eb1
Gene Name histocompatibility 2, class II antigen E beta
Synonyms H-2Eb; H2Eb; Ia-4; Ia4;
Species Mus musculus
Ensembl Gene ENSMUSG00000060586
Encoded Proteins
histocompatibility 2, class II antigen E beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196126:
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34305877-34316199
Strand Forward strand
Band B1
Transcripts
ENSMUST00000074557 ENSMUSP00000074143
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042613 MHC class II protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Hematopoietic cell lineage pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Leishmaniasis pathway
Toxoplasmosis pathway
Staphylococcus aureus infection pathway
Asthma pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
PD-1 signaling pathway
MHC class II antigen presentation pathway
TCR signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Immune System pathway
Downstream TCR signaling pathway
Interferon gamma signaling pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Generation of second messenger molecules pathway
Costimulation by the CD28 family pathway
Translocation of ZAP-70 to Immunological synapse pathway
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Hematopoietic cell lineage pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Leishmaniasis pathway
Toxoplasmosis pathway
Staphylococcus aureus infection pathway
Asthma pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
INOH
CD4 T cell receptor signaling pathway
PID BIOCARTA
The co-stimulatory signal during t-cell activation [Biocarta view]
Il 4 signaling pathway [Biocarta view]
Role of mef2d in t-cell apoptosis [Biocarta view]
Lck and fyn tyrosine kinases in initiation of tcr activation [Biocarta view]
Antigen processing and presentation [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
Activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor [Biocarta view]
PID NCI
CXCR4-mediated signaling events
TCR signaling in na´ve CD4+ T cells
IL12-mediated signaling events
IL12 signaling mediated by STAT4
Cross-References
SwissProt
TrEMBL O19448 O19450 O19451 O19471 O19472 O78196 Q61857 Q9QUH8
UniProt Splice Variant
Entrez Gene 14969
UniGene Mm.415950
RefSeq NM_010382
OMIM
CCDS CCDS37584
HPRD
IMGT
MGI ID MGI:95901
MGI Symbol H2-Eb1
EMBL AF050157 AK160485 CR974422 L15349 L15350 M14234 M14235 M14236 M14237 M74823 U13650 U13651 X00958
GenPept AAA16542 AAA16543 AAA39639 AAA39640 AAA39641 AAA39642 AAA39643 AAC05286 AAC52533 AAC52534 BAE35816 CAA25470
RNA Seq Atlas 14969