InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HLA-DRB1

Summary

InnateDB Gene

IDBG-80863.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HLA-DRB1

Gene Name

major histocompatibility complex, class II, DR beta 1

Synonyms

DRB1; DRw10; HLA-DR1B; HLA-DRB; SS1

Species

Homo sapiens

Ensembl Gene

ENSG00000196126

Encoded Proteins

IDBP-80865

major histocompatibility complex, class II, DR beta 1

IDBP-813244

major histocompatibility complex, class II, DR beta 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:32552990-32589848

Strand

Reverse strand

Band

p21.32

Transcripts

ENST00000360004	ENSP00000353099
ENST00000611060	ENSP00000480667

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0023026	MHC class II protein complex binding
GO:0032395	MHC class II receptor activity
GO:0042605	peptide antigen binding

Biological Process

GO:0002381	immunoglobulin production involved in immunoglobulin mediated immune response
GO:0002437	inflammatory response to antigenic stimulus
GO:0002455	humoral immune response mediated by circulating immunoglobulin
GO:0002506	polysaccharide assembly with MHC class II protein complex
GO:0006955	immune response
GO:0016045	detection of bacterium
GO:0019221	cytokine-mediated signaling pathway
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031295	T cell costimulation
GO:0032673	regulation of interleukin-4 production
GO:0032689	negative regulation of interferon-gamma production
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042088	T-helper 1 type immune response
GO:0042130	negative regulation of T cell proliferation
GO:0050852	T cell receptor signaling pathway
GO:0051262	protein tetramerization
GO:0060333	interferon-gamma-mediated signaling pathway
GO:2001179	regulation of interleukin-10 secretion

Cellular Component

GO:0000139	Golgi membrane
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0030658	transport vesicle membrane
GO:0030666	endocytic vesicle membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0031902	late endosome membrane
GO:0032588	trans-Golgi network membrane
GO:0042613	MHC class II protein complex
GO:0070062	extracellular vesicular exosome
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane