Version 5.4
| Bos taurus Gene: BT.88538 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-632779.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | BT.88538 | ||||||||
| Gene Name | major histocompatibility complex, class II, DRB3 precursor | ||||||||
| Synonyms | BLA-DRB3; Bota-DRB01; Bota-DRB02; Bota-DRB04; Bota-DRB07; Bota-DRB21; Bota-DRB22; LA-DRB | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000013919 | ||||||||
| Encoded Proteins |
major histocompatibility complex, class II, DRB3
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000196126:
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 23:25458594-25476944 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
MHC class II antigen presentation pathway
Downstream TCR signaling pathway
Generation of second messenger molecules pathway
Translocation of ZAP-70 to Immunological synapse pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Interferon gamma signaling pathway
PD-1 signaling pathway
Costimulation by the CD28 family pathway
TCR signaling pathway
Cytokine Signaling in Immune system pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Immune System pathway
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| KEGG |
Hematopoietic cell lineage pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Type I diabetes mellitus pathway
Allograft rejection pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Graft-versus-host disease pathway
Asthma pathway
Intestinal immune network for IgA production pathway
Viral myocarditis pathway
Leishmaniasis pathway
Staphylococcus aureus infection pathway
Toxoplasmosis pathway
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Type I diabetes mellitus pathway
Hematopoietic cell lineage pathway
Antigen processing and presentation pathway
Asthma pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Systemic lupus erythematosus pathway
Autoimmune thyroid disease pathway
Intestinal immune network for IgA production pathway
Viral myocarditis pathway
Staphylococcus aureus infection pathway
Leishmaniasis pathway
Phagosome pathway
Toxoplasmosis pathway
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| INOH |
CD4 T cell receptor signaling pathway
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| PID NCI |
CXCR4-mediated signaling events
TCR signaling in naïve CD4+ T cells
IL12-mediated signaling events
IL12 signaling mediated by STAT4
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | E7FLN0 F1MJU5 Q8MGU2 Q9GM61 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 282530 | ||||||||
| UniGene | Bt.5356 Bt.88538 | ||||||||
| RefSeq | NM_001012680 XM_005193255 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AB048811 AB610121 AJ488500 DAAA02055286 DAAA02055287 DAAA02055288 DAAA02055289 DAAA02055290 DAAA02055291 | ||||||||
| GenPept | BAB13519 BAJ65229 CAD32693 | ||||||||
| RNA Seq Atlas | 101903005 282530 | ||||||||