InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rasgrf2

Summary

InnateDB Gene

IDBG-171717.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasgrf2

Gene Name

RAS protein-specific guanine nucleotide-releasing factor 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021708

Encoded Proteins

IDBP-171771

RAS protein-specific guanine nucleotide-releasing factor 2

IDBP-534687

RAS protein-specific guanine nucleotide-releasing factor 2

IDBP-531896

RAS protein-specific guanine nucleotide-releasing factor 2

IDBP-538537

RAS protein-specific guanine nucleotide-releasing factor 2

IDBP-537476

RAS protein-specific guanine nucleotide-releasing factor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113319:
RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:91880400-92131656

Strand

Reverse strand

Band

Transcripts

ENSMUST00000099326	ENSMUSP00000096930
ENSMUST00000151408	ENSMUSP00000116892
ENSMUST00000142378	ENSMUSP00000115401
ENSMUST00000149630	ENSMUSP00000115562
ENSMUST00000146492	ENSMUSP00000116203

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity