Mus musculus Gene: Tecr
Summary
InnateDB Gene IDBG-172185.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tecr
Gene Name trans-2,3-enoyl-CoA reductase
Synonyms 2410016D23Rik; A230102P12Rik; AI173355; D17Ertd178e; Gpsn2; SC2;
Species Mus musculus
Ensembl Gene ENSMUSG00000031708
Encoded Proteins
trans-2,3-enoyl-CoA reductase
trans-2,3-enoyl-CoA reductase
trans-2,3-enoyl-CoA reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000099797:
This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:83571700-83594491
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000019382 ENSMUSP00000019382
ENSMUST00000165740 ENSMUSP00000131389
ENSMUST00000163837 ENSMUSP00000128329
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
Biological Process
GO:0006629 lipid metabolic process
GO:0006694 steroid biosynthetic process
GO:0030497 fatty acid elongation
GO:0042761 very long-chain fatty acid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Synthesis of very long-chain fatty acyl-CoAs pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Fatty Acyl-CoA Biosynthesis pathway
Triglyceride Biosynthesis pathway
KEGG
Fatty acid elongation pathway
Biosynthesis of unsaturated fatty acids pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Fatty Acyl-CoA Biosynthesis pathway
Triglyceride Biosynthesis pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Synthesis of very long-chain fatty acyl-CoAs pathway
Metabolism of lipids and lipoproteins pathway
Triglyceride Biosynthesis pathway
Metabolism pathway
Synthesis of very long-chain fatty acyl-CoAs pathway
Fatty Acyl-CoA Biosynthesis pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
KEGG
Fatty acid elongation pathway
Biosynthesis of unsaturated fatty acids pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL G3UWE1 Q14C44 Q3TAN8
UniProt Splice Variant
Entrez Gene 106529
UniGene
RefSeq NM_027179 NM_134118
OMIM
CCDS CCDS52609 CCDS40403
HPRD
IMGT
MGI ID MGI:1915408
MGI Symbol Tecr
EMBL AC151992 AK171718 BC115455 CH466525
GenPept AAI15456 BAE42630 EDL10910
RNA Seq Atlas 106529