Homo sapiens Gene: TECR
Summary
InnateDB Gene IDBG-33523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TECR
Gene Name trans-2,3-enoyl-CoA reductase
Synonyms GPSN2; MRT14; SC2; TER;
Species Homo sapiens
Ensembl Gene ENSG00000099797
Encoded Proteins
trans-2,3-enoyl-CoA reductase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:14517085-14565980
Strand Forward strand
Band p13.12
Transcripts
ENST00000215567 ENSP00000215567
ENST00000598715 ENSP00000469263
ENST00000601350
ENST00000593637
ENST00000594958
ENST00000598298 ENSP00000471341
ENST00000596073 ENSP00000472697
ENST00000601187 ENSP00000472957
ENST00000600083 ENSP00000472114
ENST00000598987 ENSP00000472504
ENST00000593775
ENST00000600395
ENST00000598918 ENSP00000473033
ENST00000596164
ENST00000599101
ENST00000596953
ENST00000599646
ENST00000601652
ENST00000597607
ENST00000601461
ENST00000594545 ENSP00000469343
ENST00000598408
ENST00000598333 ENSP00000473129
ENST00000600076
ENST00000594807
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
Biological Process
GO:0006629 lipid metabolic process
GO:0019432 triglyceride biosynthetic process
GO:0030497 fatty acid elongation
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process
GO:0042761 very long-chain fatty acid biosynthetic process
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Fatty Acyl-CoA Biosynthesis pathway
Triglyceride Biosynthesis pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Synthesis of very long-chain fatty acyl-CoAs pathway
KEGG
Fatty acid elongation pathway
Biosynthesis of unsaturated fatty acids pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.515642 Hs.657019 Hs.733316 Hs.738951
RefSeq NM_138501 XM_006722947
HUGO
OMIM
CCDS CCDS12313
HPRD 17076
IMGT
EMBL
GenPept
RNA Seq Atlas