InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TECR

Summary

InnateDB Gene

IDBG-33523.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TECR

Gene Name

trans-2,3-enoyl-CoA reductase

Synonyms

GPSN2; MRT14; SC2; TER

Species

Homo sapiens

Ensembl Gene

ENSG00000099797

Encoded Proteins

IDBP-33525

trans-2,3-enoyl-CoA reductase

IDBP-762412

IDBP-761003

IDBP-765099

IDBP-765719

IDBP-763724

IDBP-765563

IDBP-765515

IDBP-764998

IDBP-762848

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:14517085-14565980

Strand

Forward strand

Band

p13.12

Transcripts

ENST00000215567	ENSP00000215567
ENST00000598715	ENSP00000469263
ENST00000601350
ENST00000593637
ENST00000594958
ENST00000598298	ENSP00000471341
ENST00000596073	ENSP00000472697
ENST00000601187	ENSP00000472957
ENST00000600083	ENSP00000472114
ENST00000598987	ENSP00000472504
ENST00000593775
ENST00000600395
ENST00000598918	ENSP00000473033
ENST00000596164
ENST00000599101
ENST00000596953
ENST00000599646
ENST00000601652
ENST00000597607
ENST00000601461
ENST00000594545	ENSP00000469343
ENST00000598408
ENST00000598333	ENSP00000473129
ENST00000600076
ENST00000594807

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors

Biological Process

GO:0006629	lipid metabolic process
GO:0019432	triglyceride biosynthetic process
GO:0030497	fatty acid elongation
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0042761	very long-chain fatty acid biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031708

View Gene Order

ENSBTAG00000012632

Not yet available

Pathways

NETPATH

REACTOME

REACT_380

Synthesis of very long-chain fatty acyl-CoAs pathway

REACT_1319

Fatty Acyl-CoA Biosynthesis pathway

REACT_1190

Triglyceride Biosynthesis pathway

REACT_22279

Fatty acid, triacylglycerol, and ketone body metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

hsa01040

Biosynthesis of unsaturated fatty acids pathway

hsa00062

Fatty acid elongation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.515642 Hs.657019 Hs.733316 Hs.738951

RefSeq

NM_138501 XM_006722947

HUGO

OMIM

CCDS

CCDS12313

HPRD

17076

IMGT

EMBL

GenPept

RNA Seq Atlas