Mus musculus Gene: Gbf1
Summary
InnateDB Gene IDBG-172311.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gbf1
Gene Name golgi-specific brefeldin A-resistance factor 1
Synonyms 1700083E03Rik; AI035702; AW049900; mKIAA0248;
Species Mus musculus
Ensembl Gene ENSMUSG00000025224
Encoded Proteins
golgi-specific brefeldin A-resistance factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107862:
This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:46152509-46286510
Strand Forward strand
Band C3
Transcripts
ENSMUST00000026254 ENSMUSP00000026254
ENSMUST00000175747 ENSMUSP00000134762
ENSMUST00000176422
ENSMUST00000175878
ENSMUST00000175868
ENSMUST00000175706
ENSMUST00000176525
ENSMUST00000176574 ENSMUSP00000135847
ENSMUST00000176853
ENSMUST00000176355
ENSMUST00000176992 ENSMUSP00000135062
ENSMUST00000177406
ENSMUST00000176046
ENSMUST00000176576
ENSMUST00000177512 ENSMUSP00000135850
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0016192 vesicle-mediated transport
GO:0032012 regulation of ARF protein signal transduction
GO:0043087 regulation of GTPase activity
Cellular Component
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0005801 cis-Golgi network
GO:0005802 trans-Golgi network
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
trans-Golgi Network Vesicle Budding pathway
Clathrin derived vesicle budding pathway
COPI Mediated Transport pathway
Golgi to ER Retrograde Transport pathway
Membrane Trafficking pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
Adp-ribosylation factor [Biocarta view]
Thrombin signaling and protease-activated receptors [Biocarta view]
PID NCI
Arf1 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.271620
RefSeq NM_178930 XM_006526580 XM_006526581 XM_006526582 XM_006526583
OMIM
CCDS CCDS29873
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas