Homo sapiens Gene: ADRB3
Summary
InnateDB Gene IDBG-17239.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADRB3
Gene Name adrenoceptor beta 3
Synonyms BETA3AR;
Species Homo sapiens
Ensembl Gene ENSG00000188778
Encoded Proteins
adrenergic, beta-3-, receptor
adrenoceptor beta 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:37962991-37966965
Strand Reverse strand
Band p11.23
Transcripts
ENST00000345060 ENSP00000343782
ENST00000520341
ENST00000614635 ENSP00000480325
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004939 beta-adrenergic receptor activity
GO:0005515 protein binding
GO:0015052 beta3-adrenergic receptor activity
GO:0031699 beta-3 adrenergic receptor binding
GO:0042803 protein homodimerization activity
GO:0051379 epinephrine binding
GO:0051380 norepinephrine binding
Biological Process
GO:0002024 diet induced thermogenesis
GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0005975 carbohydrate metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006112 energy reserve metabolic process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007568 aging
GO:0009409 response to cold
GO:0031649 heat generation
GO:0040015 negative regulation of multicellular organism growth
GO:0042755 eating behavior
GO:0043410 positive regulation of MAPK cascade
GO:0046677 response to antibiotic
GO:0050873 brown fat cell differentiation
GO:0071875 adrenergic receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Amine ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Adrenoceptors pathway
GPCR ligand binding pathway
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
Endocytosis pathway
Salivary secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P13945
TrEMBL A8KAG8
UniProt Splice Variant
Entrez Gene 155
UniGene Hs.2549
RefSeq NM_000025
HUGO HGNC:288
OMIM 109691
CCDS CCDS6099
HPRD
IMGT
EMBL AK293033 AK313857 AY487247 BC075017 CH471080 DQ104441 M29932 S53291 X70811 X70812 X72861
GenPept AAA35550 AAB24837 AAH75017 AAR37414 AAY88743 BAF85722 BAG36585 CAA50141 CAA50142 CAA50143 CAA51383 EAW63344
RNA Seq Atlas 155