InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADRB3

Summary

InnateDB Gene

IDBG-17239.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRB3

Gene Name

adrenoceptor beta 3

Synonyms

BETA3AR

Species

Homo sapiens

Ensembl Gene

ENSG00000188778

Encoded Proteins

IDBP-17241

adrenergic, beta-3-, receptor

IDBP-810159

adrenoceptor beta 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:37962991-37966965

Strand

Reverse strand

Band

p11.23

Transcripts

ENST00000345060	ENSP00000343782
ENST00000520341
ENST00000614635	ENSP00000480325

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004939	beta-adrenergic receptor activity
GO:0005515	protein binding
GO:0015052	beta3-adrenergic receptor activity
GO:0031699	beta-3 adrenergic receptor binding
GO:0042803	protein homodimerization activity
GO:0051379	epinephrine binding
GO:0051380	norepinephrine binding

Biological Process

GO:0002024	diet induced thermogenesis
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0005975	carbohydrate metabolic process
GO:0006091	generation of precursor metabolites and energy
GO:0006112	energy reserve metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007568	aging
GO:0009409	response to cold
GO:0031649	heat generation
GO:0040015	negative regulation of multicellular organism growth
GO:0042755	eating behavior
GO:0043410	positive regulation of MAPK cascade
GO:0046677	response to antibiotic
GO:0050873	brown fat cell differentiation
GO:0071875	adrenergic receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031489

View Gene Order

ENSBTAG00000017981

Not yet available

Pathways

NETPATH

REACTOME

REACT_19327

G alpha (s) signalling events pathway

REACT_16927

Adrenoceptors pathway

REACT_16983

Amine ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04020

Calcium signaling pathway pathway

hsa04144

Endocytosis pathway

hsa04970

Salivary secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.2549

RefSeq

NM_000025

HUGO

OMIM

CCDS

CCDS6099

HPRD

00188

IMGT

EMBL

GenPept

RNA Seq Atlas