InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fzd3

Summary

InnateDB Gene

IDBG-174092.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fzd3

Gene Name

frizzled homolog 3 (Drosophila)

Synonyms

AU020229; D930050A07Rik; Fz3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000007989

Encoded Proteins

IDBP-537897

frizzled homolog 3 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104290:
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development. Alternative splicing results in multiple transcript variants. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:65201026-65262463

Strand

Reverse strand

Band

Transcripts

ENSMUST00000131309	ENSMUSP00000115325
ENSMUST00000127272

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001736	establishment of planar polarity
GO:0001764	neuron migration
GO:0001843	neural tube closure
GO:0001942	hair follicle development
GO:0001944	vasculature development
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007166	cell surface receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0008406	gonad development
GO:0021754	facial nucleus development
GO:0030901	midbrain development
GO:0033278	cell proliferation in midbrain
GO:0036342	post-anal tail morphogenesis
GO:0042472	inner ear morphogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0071679	commissural neuron axon guidance

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0032589	neuron projection membrane
GO:0043025	neuronal cell body
GO:0045177	apical part of cell
GO:0048786	presynaptic active zone