Mus musculus Gene: Grb14
Summary
InnateDB Gene IDBG-174439.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grb14
Gene Name growth factor receptor bound protein 14
Synonyms AI505286;
Species Mus musculus
Ensembl Gene ENSMUSG00000026888
Encoded Proteins
growth factor receptor bound protein 14
growth factor receptor bound protein 14
growth factor receptor bound protein 14
growth factor receptor bound protein 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115290:
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:64912476-65024987
Strand Reverse strand
Band C1.3
Transcripts
ENSMUST00000028252 ENSMUSP00000028252
ENSMUST00000149193 ENSMUSP00000118115
ENSMUST00000134020
ENSMUST00000150643 ENSMUSP00000121571
ENSMUST00000137085
ENSMUST00000156765 ENSMUSP00000121001
ENSMUST00000145603
ENSMUST00000146807
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0009967 positive regulation of signal transduction
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Hemostasis pathway
Cell surface interactions at the vascular wall pathway
Tie2 Signaling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
Tie2 Signaling pathway
Cell surface interactions at the vascular wall pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Angiopoietin receptor Tie2-mediated signaling
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.214554
RefSeq NM_016719
OMIM
CCDS CCDS16071
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas