InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grb14

Summary

InnateDB Gene

IDBG-174439.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grb14

Gene Name

growth factor receptor bound protein 14

Synonyms

AI505286

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026888

Encoded Proteins

IDBP-174441

growth factor receptor bound protein 14

IDBP-532349

growth factor receptor bound protein 14

IDBP-539727

growth factor receptor bound protein 14

IDBP-540479

growth factor receptor bound protein 14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115290:
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:64912476-65024987

Strand

Reverse strand

Band

C1.3

Transcripts

ENSMUST00000028252	ENSMUSP00000028252
ENSMUST00000149193	ENSMUSP00000118115
ENSMUST00000134020
ENSMUST00000150643	ENSMUSP00000121571
ENSMUST00000137085
ENSMUST00000156765	ENSMUSP00000121001
ENSMUST00000145603
ENSMUST00000146807

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0009967	positive regulation of signal transduction

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000115290

View Gene Order

ENSBTAG00000019291

Not yet available

Pathways

NETPATH

REACTOME

REACT_224553

Hemostasis pathway

REACT_225233

Cell surface interactions at the vascular wall pathway

REACT_211860

Tie2 Signaling pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_12621

Tie2 Signaling pathway

REACT_12051

Cell surface interactions at the vascular wall pathway

REACT_604

Hemostasis pathway

KEGG

INOH

PID NCI

angiopoietinreceptor_pathway

Angiopoietin receptor Tie2-mediated signaling

insulin_pathway

Insulin Pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.214554

RefSeq

NM_016719

OMIM

CCDS

CCDS16071

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas