Version 5.4
Bos taurus Gene: BT.36371
Summary
InnateDB Gene IDBG-641163.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.36371
Gene Name growth factor receptor-bound protein 14
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000019291
Encoded Proteins
IDBP-693492
growth factor receptor-bound protein 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115290:
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:31783357-31912200
Strand Forward strand
Band
Transcripts
ENSBTAT00000025686 ENSBTAP00000025686
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0009967 positive regulation of signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000115290
View Gene Order
ENSMUSG00000026888
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_12621
Tie2 Signaling pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
REACT_224553
Hemostasis pathway
REACT_225233
Cell surface interactions at the vascular wall pathway
REACT_211860
Tie2 Signaling pathway
KEGG
INOH
PID NCI
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
insulin_pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL F1MBA2
UniProt Splice Variant
Entrez Gene 497029
UniGene Bt.36371
RefSeq NM_001011681
HUGO HGNC:4565
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02004367 DAAA02004368
GenPept
RNA Seq Atlas 497029

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca