Version 5.4
Mus musculus Gene: Brf1
Summary
InnateDB Gene IDBG-175472.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Brf1
Gene Name BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
Synonyms 2510002F24Rik; GTF3B; mTFIIIB90; TAF3C; TAFIII90; TFIIIB90
Species Mus musculus
Ensembl Gene ENSMUSG00000011158
Encoded Proteins
IDBP-175474
BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185024:
This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:112959862-113000621
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000011302 ENSMUSP00000011302
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003743 translation initiation factor activity
GO:0008270 zinc ion binding
GO:0017025 TBP-class protein binding
Biological Process
GO:0006352 DNA-templated transcription, initiation
GO:0006413 translational initiation
GO:0043488 regulation of mRNA stability
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000185024
View Gene Order
ENSBTAG00000012753
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_1036
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_347
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_281
RNA Polymerase III Transcription Initiation pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3X8S2 Q6PED6 Q9CS04
UniProt Splice Variant
Entrez Gene 72308
UniGene
RefSeq NM_028193 XM_006516260 XM_006516261 XM_006516262 XM_006516265 XM_006516266 XM_006516267
OMIM
CCDS CCDS49195
HPRD
IMGT
MGI ID MGI:1919558
MGI Symbol Brf1
EMBL AC073562 AC160929 AK010890 BC058112 CH466549
GenPept AAH58112 BAB27249 EDL18569
RNA Seq Atlas 72308

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca