InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TXNIP

Summary

InnateDB Gene

IDBG-633552.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TXNIP

Gene Name

thioredoxin-interacting protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020060

Encoded Proteins

IDBP-685274

TXNIP proteinUncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22883233

[Homo sapiens] Hyperactivated ERN1 (IRE1α) increases TXNIP mRNA stability by reducing levels of a TXNIP destabilizing microRNA, miR-17. In turn, elevated TXNIP protein activates the NLRP3 inflammasome, causing procaspase-1 cleavage and interleukin 1β (IL-1β) secretion.

PMID 24217221

[Homo sapiens] Endoplasmic reticulum (ER) stress-mediated reactive oxygen species accumulation leads to activation of NLRP3 inflammasome through enhanced secretion of IL1B and binding of TXNIP.

PMID 22883233

[Mus musculus] Hyperactivated Ern1 (IRE1α) increases Txnip mRNA stability by reducing levels of a Txnip destabilizing microRNA, miR-17. In turn, elevated Txnip protein activates the Nlrp3 inflammasome, causing procaspase-1 cleavage and interleukin 1β (IL-1β) secretion. (Demonstrated in human)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog null:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:21489097-21493251

Strand

Forward strand

Band

Transcripts

ENSBTAT00000026724

ENSBTAP00000026724

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006606	protein import into nucleus
GO:0006979	response to oxidative stress
GO:0030216	keratinocyte differentiation
GO:0043086	negative regulation of catalytic activity
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0051782	negative regulation of cell division
GO:0071228	cellular response to tumor cell