Mus musculus Gene: Pias3
Summary
InnateDB Gene IDBG-176105.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pias3
Gene Name protein inhibitor of activated STAT 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000028101
Encoded Proteins
protein inhibitor of activated STAT 3
protein inhibitor of activated STAT 3
protein inhibitor of activated STAT 3
protein inhibitor of activated STAT 3
protein inhibitor of activated STAT 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] MIR21 inhibition enhances CCL5 (RANTES) and CXCL10 (IP-10) release in MCF-7 cancer cells and resulted in increased lymphocyte migration . PIAS3 is a target of MIR21 in MCF-7 cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131788:
This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:96696384-96706070
Strand Forward strand
Band F2.1
Transcripts
ENSMUST00000064900 ENSMUSP00000069259
ENSMUST00000107077 ENSMUSP00000102692
ENSMUST00000107076 ENSMUSP00000102691
ENSMUST00000162934 ENSMUSP00000125747
ENSMUST00000162778 ENSMUSP00000125377
ENSMUST00000162707
ENSMUST00000161296
ENSMUST00000162156 ENSMUSP00000135843
ENSMUST00000176302 ENSMUSP00000134835
ENSMUST00000176288
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 17 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 47 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008270 zinc ion binding
GO:0015459 potassium channel regulator activity
GO:0019789 SUMO ligase activity
GO:0019899 enzyme binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009725 response to hormone
GO:0010628 positive regulation of gene expression
GO:0016925 protein sumoylation
GO:0033235 positive regulation of protein sumoylation
GO:0045838 positive regulation of membrane potential
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030425 dendrite
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Ubiquitin mediated proteolysis pathway
Jak-STAT signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
AndrogenReceptor pathway
EGFR1 pathway
TNFalpha pathway
IL6 pathway
Prolactin pathway
IL11 pathway
Oncostatin_M pathway
REACTOME
KEGG
Ubiquitin mediated proteolysis pathway
Jak-STAT signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Coregulation of Androgen receptor activity
C-MYB transcription factor network
Regulation of nuclear SMAD2/3 signaling
IL6-mediated signaling events
Cross-References
SwissProt O54714
TrEMBL E0CZ31 E0CZH5 H3BJ41 Q3TM95 Q3UYT2
UniProt Splice Variant
Entrez Gene 229615
UniGene
RefSeq NM_001165949 NM_018812 NM_146135 XM_006501393 XM_006501394
OMIM
CCDS CCDS17645 CCDS38559 CCDS51007
HPRD
IMGT
MGI ID MGI:1913126
MGI Symbol Pias3
EMBL AC112261 AF034080 AK040619 AK077551 AK134404 AK166054 BC023128 BC051252
GenPept AAB88902 AAH23128 AAH51252 BAC30647 BAC36858 BAE22129 BAE38547
RNA Seq Atlas 229615