InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prickle1

Summary

InnateDB Gene

IDBG-176871.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prickle1

Gene Name

prickle homolog 1 (Drosophila)

Synonyms

1110058P22Rik; AW215793; b2b019Clo; mpk1; Prickle

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036158

Encoded Proteins

IDBP-176873

prickle homolog 1 (Drosophila)

IDBP-262783

prickle homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139174:
This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:93499114-93595891

Strand

Reverse strand

Band

Transcripts

ENSMUST00000048982	ENSMUSP00000049204
ENSMUST00000109255	ENSMUSP00000104878

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0001843	neural tube closure
GO:0006606	protein import into nucleus
GO:0031398	positive regulation of protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2000691	negative regulation of cardiac muscle cell myoblast differentiation