Version 5.4
Bos taurus Gene: BT.57449
Summary
InnateDB Gene IDBG-633363.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.57449
Gene Name prickle-like protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008596
Encoded Proteins
IDBP-685065
prickle-like protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139174:
This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:38273723-38388071
Strand Forward strand
Band
Transcripts
ENSBTAT00000011340 ENSBTAP00000011340
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0001843 neural tube closure
GO:0006606 protein import into nucleus
GO:0031398 positive regulation of protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000691 negative regulation of cardiac muscle cell myoblast differentiation
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000139174
View Gene Order
ENSMUSG00000036158
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_172581
PCP/CE pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_172638
Asymmetric localization of PCP proteins pathway
REACT_214014
Signaling by Wnt pathway
REACT_226355
beta-catenin independent WNT signaling pathway
REACT_214043
PCP/CE pathway pathway
REACT_203973
Asymmetric localization of PCP proteins pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa04310
Wnt signaling pathway pathway
mmu04310
Wnt signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MZ06
UniProt Splice Variant
Entrez Gene 785152
UniGene Bt.57449
RefSeq NM_001102534
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02013076 DAAA02013077 DAAA02013078 DAAA02013079 DAAA02013080
GenPept
RNA Seq Atlas 785152

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca