Version 5.4
Homo sapiens Gene: PRICKLE1
Summary
InnateDB Gene IDBG-27853.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRICKLE1
Gene Name prickle homolog 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139174
Encoded Proteins
IDBP-27855
prickle homolog 1 (Drosophila)
IDBP-372458
prickle homolog 1 (Drosophila)
IDBP-372460
prickle homolog 1 (Drosophila)
IDBP-598763
prickle homolog 1 (Drosophila)
IDBP-603183
prickle homolog 1 (Drosophila)
IDBP-599874
prickle homolog 1 (Drosophila)
IDBP-592383
prickle homolog 1 (Drosophila)
IDBP-602328
prickle homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:42456754-42590355
Strand Reverse strand
Band q12
Transcripts
ENST00000345127 ENSP00000345064
ENST00000455697 ENSP00000401060
ENST00000445766 ENSP00000398947
ENST00000548696 ENSP00000448359
ENST00000552240 ENSP00000449819
ENST00000552108 ENSP00000447870
ENST00000551050 ENSP00000446970
ENST00000547113 ENSP00000446699
ENST00000552200
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0001843 neural tube closure
GO:0006606 protein import into nucleus
GO:0031398 positive regulation of protein ubiquitination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000691 negative regulation of cardiac muscle cell myoblast differentiation
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036158
View Gene Order
ENSBTAG00000008596
Not yet available
Pathways
NETPATH
REACTOME
REACT_172581
PCP/CE pathway pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_172638
Asymmetric localization of PCP proteins pathway
KEGG
hsa04310
Wnt signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q96MT3
TrEMBL A0A024R0W7 F8VUG8 F8W1J1 F8W1Q8 Q687H3 Q687H4
UniProt Splice Variant
Entrez Gene 144165
UniGene Hs.720221
RefSeq NM_001144881 NM_001144882 NM_001144883 NM_153026
HUGO HGNC:17019
OMIM 608500
CCDS CCDS8742
HPRD 16341
IMGT
EMBL AC079600 AC079601 AF399844 AF543759 AF543760 AK056189 AK056499 BC114939 BC114940 CH471111
GenPept AAI14940 AAI14941 AAQ03035 AAQ11824 AAQ11825 BAB71116 BAB71198 EAW57854 EAW57855
RNA Seq Atlas 144165

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca