InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nppc

Summary

InnateDB Gene

IDBG-177177.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nppc

Gene Name

natriuretic peptide type C

Synonyms

CNP; lbab

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026241

Encoded Proteins

IDBP-177179

natriuretic peptide type C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the natriuretic peptide family. Natriuretic peptides are involved in the control of blood pressure, extracellular fluid volume and electrolyte homeostasis. The encoded protein also plays a role in sensory neuron bifurcation, and is a critical regulator of endochondral bone growth. The encoded protein is a ligand for the natriuretic peptide receptor B, and is synthesized as a preprohormone which is cleaved to produce a mature peptide. Mutations in this gene are associated with dwarfism resulting from impaired endochondral ossification. [provided by RefSeq, Apr 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:86666291-86670571

Strand

Reverse strand

Band

Transcripts

ENSMUST00000027449

ENSMUSP00000027449

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0005184	neuropeptide hormone activity
GO:0042803	protein homodimerization activity
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0001503	ossification
GO:0001666	response to hypoxia
GO:0003418	growth plate cartilage chondrocyte differentiation
GO:0003419	growth plate cartilage chondrocyte proliferation
GO:0006182	cGMP biosynthetic process
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0009791	post-embryonic development
GO:0030814	regulation of cAMP metabolic process
GO:0030823	regulation of cGMP metabolic process
GO:0030828	positive regulation of cGMP biosynthetic process
GO:0040014	regulation of multicellular organism growth
GO:0042493	response to drug
GO:0044702	single organism reproductive process
GO:0045471	response to ethanol
GO:0045669	positive regulation of osteoblast differentiation
GO:0045909	positive regulation of vasodilation
GO:0048513	organ development
GO:0048660	regulation of smooth muscle cell proliferation
GO:0050880	regulation of blood vessel size
GO:0051053	negative regulation of DNA metabolic process
GO:0051447	negative regulation of meiotic cell cycle
GO:1900194	negative regulation of oocyte maturation

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0030141	secretory granule

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000163273

View Gene Order

ENSBTAG00000003253

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.12802 Mm.488919

RefSeq

NM_010933

OMIM

CCDS

CCDS15123

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas