Mus musculus Gene: Nppc
InnateDB Gene IDBG-177177.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nppc
Gene Name natriuretic peptide type C
Synonyms CNP; lbab;
Species Mus musculus
Ensembl Gene ENSMUSG00000026241
Encoded Proteins
natriuretic peptide type C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the natriuretic peptide family. Natriuretic peptides are involved in the control of blood pressure, extracellular fluid volume and electrolyte homeostasis. The encoded protein also plays a role in sensory neuron bifurcation, and is a critical regulator of endochondral bone growth. The encoded protein is a ligand for the natriuretic peptide receptor B, and is synthesized as a preprohormone which is cleaved to produce a mature peptide. Mutations in this gene are associated with dwarfism resulting from impaired endochondral ossification. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:86666291-86670571
Strand Reverse strand
Band C5
ENSMUST00000027449 ENSMUSP00000027449
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0042803 protein homodimerization activity
GO:0051428 peptide hormone receptor binding
Biological Process
GO:0001503 ossification
GO:0001666 response to hypoxia
GO:0003418 growth plate cartilage chondrocyte differentiation
GO:0003419 growth plate cartilage chondrocyte proliferation
GO:0006182 cGMP biosynthetic process
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0009791 post-embryonic development
GO:0030814 regulation of cAMP metabolic process
GO:0030823 regulation of cGMP metabolic process
GO:0030828 positive regulation of cGMP biosynthetic process
GO:0040014 regulation of multicellular organism growth
GO:0042493 response to drug
GO:0044702 single organism reproductive process
GO:0045471 response to ethanol
GO:0045669 positive regulation of osteoblast differentiation
GO:0045909 positive regulation of vasodilation
GO:0048513 organ development
GO:0048660 regulation of smooth muscle cell proliferation
GO:0050880 regulation of blood vessel size
GO:0051053 negative regulation of DNA metabolic process
GO:0051447 negative regulation of meiotic cell cycle
GO:1900194 negative regulation of oocyte maturation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0030141 secretory granule
Homo sapiens
Bos taurus
Gene ID
Gene Order
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
SwissProt Q61839
UniProt Splice Variant
Entrez Gene 18159
UniGene Mm.12802 Mm.488919
RefSeq NM_010933
MGI ID MGI:97369
MGI Symbol Nppc
EMBL AK036176 BC111834 CH466520 D28873 D84665 U62939
GenPept AAB61717 AAI11835 BAA06028 BAC29333 BAF79933 EDL40200
RNA Seq Atlas 18159