InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NPPC

Summary

InnateDB Gene

IDBG-83164.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPPC

Gene Name

natriuretic peptide C

Synonyms

CNP; CNP2

Species

Homo sapiens

Ensembl Gene

ENSG00000163273

Encoded Proteins

IDBP-83166

natriuretic peptide C

IDBP-292910

natriuretic peptide C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is proteolytically processed to form a secreted hormone of the natriuretic peptide family. The encoded hormone regulates the growth and differentiation of cartilaginous growth plate chondrocytes and may also be vasoactive and natriuretic. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:231921820-231926403

Strand

Reverse strand

Band

q37.1

Transcripts

ENST00000295440	ENSP00000295440
ENST00000409852	ENSP00000387159

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0042803	protein homodimerization activity
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0001503	ossification
GO:0001666	response to hypoxia
GO:0003418	growth plate cartilage chondrocyte differentiation
GO:0003419	growth plate cartilage chondrocyte proliferation
GO:0006182	cGMP biosynthetic process
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0009791	post-embryonic development
GO:0030814	regulation of cAMP metabolic process
GO:0030823	regulation of cGMP metabolic process
GO:0030828	positive regulation of cGMP biosynthetic process
GO:0040014	regulation of multicellular organism growth
GO:0042493	response to drug
GO:0044702	single organism reproductive process
GO:0045471	response to ethanol
GO:0045669	positive regulation of osteoblast differentiation
GO:0045909	positive regulation of vasodilation
GO:0048513	organ development
GO:0048660	regulation of smooth muscle cell proliferation
GO:0050880	regulation of blood vessel size
GO:0051053	negative regulation of DNA metabolic process
GO:0051447	negative regulation of meiotic cell cycle
GO:1900194	negative regulation of oocyte maturation

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0030141	secretory granule

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000026241

View Gene Order

ENSBTAG00000003253

Not yet available

Cross-References

SwissProt

P23582

TrEMBL

E5LCN7

UniProt Splice Variant

Entrez Gene

4880

UniGene

Hs.627236

RefSeq

NM_024409

HUGO

HGNC:7941

OMIM

600296

CCDS

CCDS2489

HPRD

08975

IMGT

EMBL

AC013435 BC069120 BC105065 BC105067 D90337 HQ419060 JF420840 M64710

GenPept

AAA35703 AAH69120 AAI05066 AAI05068 AAX88912 ADQ54381 ADZ36320 BAA14351

RNA Seq Atlas

4880