Homo sapiens Gene: NPPC
Summary
InnateDB Gene IDBG-83164.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NPPC
Gene Name natriuretic peptide C
Synonyms CNP; CNP2;
Species Homo sapiens
Ensembl Gene ENSG00000163273
Encoded Proteins
natriuretic peptide C
natriuretic peptide C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is proteolytically processed to form a secreted hormone of the natriuretic peptide family. The encoded hormone regulates the growth and differentiation of cartilaginous growth plate chondrocytes and may also be vasoactive and natriuretic. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:231921820-231926403
Strand Reverse strand
Band q37.1
Transcripts
ENST00000295440 ENSP00000295440
ENST00000409852 ENSP00000387159
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0042803 protein homodimerization activity
GO:0051428 peptide hormone receptor binding
Biological Process
GO:0001503 ossification
GO:0001666 response to hypoxia
GO:0003418 growth plate cartilage chondrocyte differentiation
GO:0003419 growth plate cartilage chondrocyte proliferation
GO:0006182 cGMP biosynthetic process
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0008285 negative regulation of cell proliferation
GO:0009791 post-embryonic development
GO:0030814 regulation of cAMP metabolic process
GO:0030823 regulation of cGMP metabolic process
GO:0030828 positive regulation of cGMP biosynthetic process
GO:0040014 regulation of multicellular organism growth
GO:0042493 response to drug
GO:0044702 single organism reproductive process
GO:0045471 response to ethanol
GO:0045669 positive regulation of osteoblast differentiation
GO:0045909 positive regulation of vasodilation
GO:0048513 organ development
GO:0048660 regulation of smooth muscle cell proliferation
GO:0050880 regulation of blood vessel size
GO:0051053 negative regulation of DNA metabolic process
GO:0051447 negative regulation of meiotic cell cycle
GO:1900194 negative regulation of oocyte maturation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0030141 secretory granule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.627236
RefSeq NM_024409
HUGO
OMIM
CCDS CCDS2489
HPRD 08975
IMGT
EMBL
GenPept
RNA Seq Atlas