InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ssb

Summary

InnateDB Gene

IDBG-177350.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ssb

Gene Name

Sjogren syndrome antigen B

Synonyms

SS-B

Species

Mus musculus

Ensembl Gene

ENSMUSG00000068882

Encoded Proteins

IDBP-177352

Sjogren syndrome antigen B

IDBP-256385

Sjogren syndrome antigen B

IDBP-536671

Sjogren syndrome antigen B

IDBP-535006

Sjogren syndrome antigen B

IDBP-627925

Sjogren syndrome antigen B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138385:
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. [provided by RefSeq, Nov 2011]
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5\' and 3\' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:69861562-69871846

Strand

Forward strand

Band

Transcripts

ENSMUST00000090852	ENSMUSP00000088365
ENSMUST00000112260	ENSMUSP00000107879
ENSMUST00000132186	ENSMUSP00000119773
ENSMUST00000156057
ENSMUST00000132603	ENSMUSP00000115666
ENSMUST00000166411	ENSMUSP00000130313

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding