Version 5.4
Mus musculus Gene: Abcc12
Summary
InnateDB Gene IDBG-177767.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Abcc12
Gene Name ATP-binding cassette, sub-family C (CFTR/MRP), member 12
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000036872
Encoded Proteins
IDBP-177769
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
IDBP-540471
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
IDBP-535066
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
IDBP-534991
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
IDBP-535096
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
IDBP-536712
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
IDBP-536635
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140798:
This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:86482260-86580686
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000080115 ENSMUSP00000079014
ENSMUST00000129898 ENSMUSP00000122577
ENSMUST00000131423 ENSMUSP00000122402
ENSMUST00000156066 ENSMUSP00000120282
ENSMUST00000131806 ENSMUSP00000116866
ENSMUST00000156610 ENSMUSP00000123578
ENSMUST00000152438 ENSMUSP00000114582
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000140798
View Gene Order
ENSBTAG00000044191
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu02010
ABC transporters pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa02010
ABC transporters pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6RCU5
UniProt Splice Variant
Entrez Gene 244562
UniGene Mm.401968 Mm.67485
RefSeq NM_172912 XM_006530984 XM_006530985 XM_006530986
OMIM
CCDS CCDS22502
HPRD
IMGT
MGI ID MGI:2441679
MGI Symbol Abcc12
EMBL AC132147 AC159262
GenPept
RNA Seq Atlas 244562

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca