Mus musculus Gene: Phgdh
Summary
InnateDB Gene IDBG-177951.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Phgdh
Gene Name 3-phosphoglycerate dehydrogenase
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000053398
Encoded Proteins
3-phosphoglycerate dehydrogenase
3-phosphoglycerate dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092621:
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:98313170-98339990
Strand Reverse strand
Band F2.2
Transcripts
ENSMUST00000065793 ENSMUSP00000064755
ENSMUST00000153694
ENSMUST00000152106
ENSMUST00000148488 ENSMUSP00000117525
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004617 phosphoglycerate dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0006541 glutamine metabolic process
GO:0006544 glycine metabolic process
GO:0006563 L-serine metabolic process
GO:0006564 L-serine biosynthetic process
GO:0006566 threonine metabolic process
GO:0008152 metabolic process
GO:0009448 gamma-aminobutyric acid metabolic process
GO:0010468 regulation of gene expression
GO:0019530 taurine metabolic process
GO:0021510 spinal cord development
GO:0021782 glial cell development
GO:0021915 neural tube development
GO:0022008 neurogenesis
GO:0031175 neuron projection development
GO:0055114 oxidation-reduction process
GO:0070314 G1 to G0 transition
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Metabolism pathway
Serine biosynthesis pathway
Metabolism of amino acids and derivatives pathway
Amino acid synthesis and interconversion (transamination) pathway
KEGG
Glycine, serine and threonine metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Amino acid synthesis and interconversion (transamination) pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
Serine biosynthesis pathway
Metabolism of amino acids and derivatives pathway
Serine biosynthesis pathway
Metabolism pathway
Amino acid synthesis and interconversion (transamination) pathway
KEGG
Glycine, serine and threonine metabolism pathway
INOH
Glycine Serine metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.16898 Mm.323620 Mm.371997 Mm.467271 Mm.473139
RefSeq NM_016966
OMIM
CCDS CCDS17663
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas