InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pfkfb1

Summary

InnateDB Gene

IDBG-178179.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pfkfb1

Gene Name

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Synonyms

PFK/FBPase 1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025271

Encoded Proteins

IDBP-178181

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

IDBP-255435

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

IDBP-537527

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158571:
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:150588229-150643878

Strand

Forward strand

Band

Transcripts

ENSMUST00000080884	ENSMUSP00000079692
ENSMUST00000112713	ENSMUSP00000108333
ENSMUST00000153221	ENSMUSP00000115844
ENSMUST00000124381
ENSMUST00000150783
ENSMUST00000142848
ENSMUST00000154528

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003873	6-phosphofructo-2-kinase activity
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0019900	kinase binding
GO:0042802	identical protein binding
GO:0070095	fructose-6-phosphate binding

Biological Process

GO:0006000	fructose metabolic process
GO:0006003	fructose 2,6-bisphosphate metabolic process
GO:0016311	dephosphorylation
GO:0031100	organ regeneration
GO:0032868	response to insulin
GO:0033133	positive regulation of glucokinase activity
GO:0033762	response to glucagon
GO:0042594	response to starvation
GO:0046835	carbohydrate phosphorylation
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP